{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T12:39:20Z","timestamp":1785501560965,"version":"3.56.0"},"reference-count":21,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Scientific World Journal"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p><jats:italic>Purpose<\/jats:italic>. To evaluate the efficacy of using topical cyclosporin A 0.05% (Restasis) for the treatment of paediatric allergic conjunctivitis.<jats:italic>Methods<\/jats:italic>. This retrospective study included consecutive cases of paediatric allergic conjunctivitis treated with Restasis between 2010 and 2013. Subjects with follow-up time less than 3 months after using Restasis were excluded. Itch severity score, symptom score, and sign score were compared before (baseline) and 3 months after using Restasis.<jats:italic>Results<\/jats:italic>. In 27 eyes of 14 patients (mean age<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mn>10.8<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>3.2<\/mml:mn><\/mml:math>years), 44.4% had allergic conjunctivitis, 33.3% had vernal keratoconjunctivitis, and 22.2% had atopic keratoconjunctivitis. The mean duration of ocular symptoms was<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mn>20.4<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>13.2<\/mml:mn><\/mml:math>months. 92.6% of subjects were using steroid eye drop before Restasis. After 3 months of topical Restasis, there were statistically significant reductions in the symptom, sign, and itch severity scores compared with baseline (all<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>P<\/mml:mi><mml:mo>\u2264<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>) and 78.6% of subjects were able to be tapered off steroid eye drops.<jats:italic>Conclusion<\/jats:italic>. Topical Restasis was effective and safe in significantly reducing ocular itchiness, sign, and symptom scores at 3 months after use in paediatric allergic ocular conditions.<\/jats:p>","DOI":"10.1155\/2014\/396987","type":"journal-article","created":{"date-parts":[[2014,10,15]],"date-time":"2014-10-15T21:07:25Z","timestamp":1413407245000},"page":"1-5","source":"Crossref","is-referenced-by-count":10,"title":["Retrospective Review on the Use of Topical Cyclosporin A 0.05% for Paediatric Allergic Conjunctivitis in Hong Kong Chinese"],"prefix":"10.1155","volume":"2014","author":[{"given":"Macy M. S.","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Caritas Medical Center, 111 Wing Hong Street, Kowloon, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordon S. K.","family":"Yau","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Caritas Medical Center, 111 Wing Hong Street, Kowloon, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacky W. Y.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Caritas Medical Center, 111 Wing Hong Street, Kowloon, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy L.","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Caritas Medical Center, 111 Wing Hong Street, Kowloon, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor T. Y.","family":"Tam","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Caritas Medical Center, 111 Wing Hong Street, Kowloon, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Can Y. F.","family":"Yuen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Caritas Medical Center, 111 Wing Hong Street, Kowloon, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"98","reference":[{"issue":"2","key":"1","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1177\/112067211002000201","volume":"20","year":"2010","journal-title":"European Journal of Ophthalmology"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1080\/09286580590967781"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.87.9.1195-a"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1097\/00055735-199508000-00005"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0420.2000.tb01094.x"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.1997.tb00156.x"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0b013e3283292256"},{"issue":"3","key":"8","first-page":"4","volume":"6","year":"2010","journal-title":"Journal of Paediatric Respirology and Critical Care"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(98)99043-1"},{"issue":"3","key":"11","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.ophtha.2003.05.035","volume":"111","journal-title":"Ophthalmology"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e31812dfab3"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1007\/s10384-008-0577-z"},{"issue":"3","key":"14","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1177\/039463201002300322","volume":"23","year":"2010","journal-title":"International Journal of Immunopathology and Pharmacology"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1221"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.3109\/09546634.2014.906033"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2004.10.042"},{"key":"18","first-page":"11","volume":"19","year":"2009","journal-title":"Journal of Investigational Allergology and Clinical Immunology"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0b013e32834a9676"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2013.03.044"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1139\/i09-117"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1080\/20786204.2004.10873115"}],"container-title":["The Scientific World Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/tswj\/2014\/396987.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/tswj\/2014\/396987.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/tswj\/2014\/396987.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,16]],"date-time":"2019-08-16T07:08:41Z","timestamp":1565939321000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/tswj\/2014\/396987\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":21,"alternative-id":["396987","396987"],"URL":"https:\/\/doi.org\/10.1155\/2014\/396987","relation":{},"ISSN":["2356-6140","1537-744X"],"issn-type":[{"value":"2356-6140","type":"print"},{"value":"1537-744X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}