{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:47:00Z","timestamp":1787017620360,"version":"build-2736575974"},"reference-count":28,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Fundamental Research Funds for the Central University","award":["4101017"],"award-info":[{"award-number":["4101017"]}]},{"name":"Fundamental Research Funds for the Central University","award":["2013A05"],"award-info":[{"award-number":["2013A05"]}]},{"name":"Natural Science Foundation of\u00a0\u00a0Zhongnan Hospital Wuhan University","award":["4101017"],"award-info":[{"award-number":["4101017"]}]},{"name":"Natural Science Foundation of\u00a0\u00a0Zhongnan Hospital Wuhan University","award":["2013A05"],"award-info":[{"award-number":["2013A05"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Diabetes Research"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>\n                    This study aimed to investigate the expression of C1q\/TNF-related protein-3 (CTRP3) in rats at different pathogenic stages of type 2 diabetes mellitus (T2DM) and the impacts of glucagon-like peptide-1 (GLP-1) receptor agonist on it. Male wistar rats were fed with high-fat diet for 10 weeks to induce insulin resistance (IR) and then were given low-dose streptozotocin (STZ) intraperitoneal injection to induce T2DM. Exendin-4 (Ex-4), a GLP-1 receptor agonist, was subcutaneous injected to the IR rats and T2DM rats for 4 weeks. The expression of CTRP3 mRNA and protein in epididymis adipose tissue of rats at the stage of IR was lower significantly than that of normal control (NC) rats and decreased more when they were at the stage of overt T2DM (all\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                      <mml:mi>P<\/mml:mi>\n                      <mml:mo>&lt;<\/mml:mo>\n                      <mml:mn>0.05<\/mml:mn>\n                    <\/mml:math>\n                    or\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                      <mml:mi>P<\/mml:mi>\n                      <mml:mo>&lt;<\/mml:mo>\n                      <mml:mn>0.01<\/mml:mn>\n                    <\/mml:math>\n                    ). After the treatment with Ex-4, the mRNA and protein expressions of CTRP3 were increased by 15.5%\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                      <mml:mo stretchy=\"false\">(<\/mml:mo>\n                      <mml:mi>P<\/mml:mi>\n                      <mml:mo>&lt;<\/mml:mo>\n                      <mml:mn>0.01<\/mml:mn>\n                      <mml:mo stretchy=\"false\">)<\/mml:mo>\n                    <\/mml:math>\n                    and 14.8%\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                      <mml:mo stretchy=\"false\">(<\/mml:mo>\n                      <mml:mi>P<\/mml:mi>\n                      <mml:mo>&lt;<\/mml:mo>\n                      <mml:mn>0.05<\/mml:mn>\n                      <mml:mo>),<\/mml:mo>\n                    <\/mml:math>\n                    respectively, in IR rats and increased by 20.6%\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                      <mml:mo stretchy=\"false\">(<\/mml:mo>\n                      <mml:mi>P<\/mml:mi>\n                      <mml:mo>&lt;<\/mml:mo>\n                      <mml:mn>0.01<\/mml:mn>\n                      <mml:mo stretchy=\"false\">)<\/mml:mo>\n                    <\/mml:math>\n                    and 16.5%\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\">\n                      <mml:mo stretchy=\"false\">(<\/mml:mo>\n                      <mml:mi>P<\/mml:mi>\n                      <mml:mo>&lt;<\/mml:mo>\n                      <mml:mn>0.05<\/mml:mn>\n                      <mml:mo>),<\/mml:mo>\n                    <\/mml:math>\n                    respectively, in T2DM rats. Overall, this study found that the expression of CTRP3 in visceral adipose tissue was progressively decreased in a T2DM rat model from the pathogenic stage of IR to overt diabetes, while Ex-4 treatment increased its expression in such animals.\n                  <\/jats:p>","DOI":"10.1155\/2014\/398518","type":"journal-article","created":{"date-parts":[[2014,8,11]],"date-time":"2014-08-11T17:06:05Z","timestamp":1407776765000},"page":"1-6","source":"Crossref","is-referenced-by-count":23,"title":["Expression of CTRP3, a Novel Adipokine, in Rats at Different Pathogenic Stages of Type 2 Diabetes Mellitus and the Impacts of GLP-1 Receptor Agonist on It"],"prefix":"10.1155","volume":"2014","author":[{"given":"Xin","family":"Li","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Zhongnan Hospital, Wuhan University, Wuhan 430071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Zhongnan Hospital, Wuhan University, Wuhan 430071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Zhongnan Hospital, Wuhan University, Wuhan 430071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-wen","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Zhongnan Hospital, Wuhan University, Wuhan 430071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su-xin","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Zhongnan Hospital, Wuhan University, Wuhan 430071, 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