{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:48:34Z","timestamp":1787017714099,"version":"build-2736575974"},"reference-count":40,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Ophthalmology"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>\n                    <jats:italic>Objective<\/jats:italic>\n                    . To investigate the biomechanical characteristics of the cornea in patients with mitral valve prolapse (MVP) and the prevalence of keratoconus (KC) in MVP.\n                    <jats:italic>Materials and Methods<\/jats:italic>\n                    . Fifty-two patients with MVP, 39 patients with KC, and 45 control individuals were recruited in this study. All the participants underwent ophthalmologic examination, corneal analysis with the Sirius system (CSO), and the corneal biomechanical evaluation with Reichert ocular response analyzer (ORA).\n                    <jats:italic>Results<\/jats:italic>\n                    . KC was found in six eyes of four patients (5.7%) and suspect KC in eight eyes of five patients (7.7%) in the MVP group. KC was found in one eye of one patient (1.1%) in the control group (\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                      <mml:mi>P<\/mml:mi>\n                      <mml:mo>=<\/mml:mo>\n                      <mml:mn>0.035<\/mml:mn>\n                    <\/mml:math>\n                    ). A significant difference occurred in the mean CH and CRF between the MVP and control groups (\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                      <mml:mi>P<\/mml:mi>\n                      <mml:mo>=<\/mml:mo>\n                      <mml:mn>0.006<\/mml:mn>\n                    <\/mml:math>\n                    and\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                      <mml:mi>P<\/mml:mi>\n                      <mml:mo>=<\/mml:mo>\n                      <mml:mn>0.009<\/mml:mn>\n                    <\/mml:math>\n                    , resp.). All corneal biomechanical and topographical parameters except IOPcc were significantly different between the KC-MVP groups (\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                      <mml:mi>P<\/mml:mi>\n                      <mml:mo>&lt;<\/mml:mo>\n                      <mml:mn>0.05<\/mml:mn>\n                    <\/mml:math>\n                    ).\n                    <jats:italic>Conclusions<\/jats:italic>\n                    . KC prevalence is higher than control individuals in MVP patients and the biomechanical properties of the cornea are altered in patients with MVP. These findings should be considered when the MVP patients are evaluated before refractive surgery.\n                  <\/jats:p>","DOI":"10.1155\/2014\/402193","type":"journal-article","created":{"date-parts":[[2014,4,17]],"date-time":"2014-04-17T21:17:45Z","timestamp":1397769465000},"page":"1-6","source":"Crossref","is-referenced-by-count":25,"title":["Impaired Corneal Biomechanical Properties and the Prevalence of Keratoconus in Mitral Valve Prolapse"],"prefix":"10.1155","volume":"2014","author":[{"given":"Emine","family":"Kalkan Akcay","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Ankara Ataturk Training and Research Hospital, Yildirim Beyazit University, 06810 Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murat","family":"Akcay","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Ankara Ataturk Training and Research Hospital, Yildirim Beyazit University, 06810 Ankara, 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