{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T21:45:21Z","timestamp":1766180721354,"version":"3.37.3"},"reference-count":12,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Rheumatology"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p><jats:italic>Purpose.<\/jats:italic>To report a case of a patient with rheumatoid arthritis (RA) treated with tofacitinib citrate.<jats:italic>Methods.<\/jats:italic>Observational case report.<jats:italic>Results.<\/jats:italic>A 59-year-old patient, with a history of rheumatoid arthritis, on methotrexate 10\u2009mg PO qwk and IV abatacept 750\u2009mg\/month, presented with photosensitivity, foreign body sensation, pain, redness, and blurry vision of her right eye (RE). Visual acuity of the RE was 20\/200 and 20\/20 of the left eye (LE). The slit lamp examination of the RE revealed dryness, 2+ injection of the conjunctiva, and pericentral ulceration of the cornea with 20\u201330% stromal thinning, pannus, and diffuse punctate epithelial erosions. The anterior chamber appeared normal. Laboratory values revealed elevated levels of rheumatoid factor, anticyclic citrullinated peptide antibodies, and C-reactive protein. The patient was switched to tofacitinib citrate 5\u2009mg PO b.i.d, underwent corneal gluing, and was given prednisone acetate 1% gt TID, polytrim gt TID, neomycin-polymyxin-dexameth gt QD, FreshKote lubricant 1.8% gt QID, moxifloxacin 0.5% gt QID, and preservative free artificial tears Q1H. Within one week, laboratory values normalized, symptoms diminished, and the cornea reepithelialized.<jats:italic>Conclusion.<\/jats:italic>RA can present with ulcerative keratitis. Tofacitinib citrate, steroids, and corneal gluing were found to halt the progression of keratolysis and promote reepithelialization.<\/jats:p>","DOI":"10.1155\/2014\/403452","type":"journal-article","created":{"date-parts":[[2014,6,17]],"date-time":"2014-06-17T17:03:06Z","timestamp":1403024586000},"page":"1-3","source":"Crossref","is-referenced-by-count":6,"title":["Tofacitinib Citrate for Ulcerative Keratitis in a Patient with Rheumatoid Arthritis"],"prefix":"10.1155","volume":"2014","author":[{"given":"Philip B.","family":"Meadow","sequence":"first","affiliation":[{"name":"Rivertown Rheumatology P.C., Columbus Regional Health, Columbus, GA 31901, USA"},{"name":"Kirksville College of Osteopathic Medicine, Kirksville, MO 63501, USA"},{"name":"Warren General Hospital, Warren, PA 16365, USA"},{"name":"Western Reserve Health Care System, Youngstown, OH 44501, USA"},{"name":"Wilford Hall Medical Center, Lackland Air Force Base, San Antonio, TX 78236, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8917-7253","authenticated-orcid":true,"given":"Jacqueline","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Philadelphia College of Osteopathic Medicine, Suwanee, GA 30024, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6303-4994","authenticated-orcid":true,"given":"Keerthana","family":"Kesavarapu","sequence":"additional","affiliation":[{"name":"Philadelphia College of Osteopathic Medicine, Suwanee, GA 30024, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2012.09.050"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.12659\/AJCR.883998"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kep390"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.87.5.548"},{"issue":"12","key":"5","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1136\/bjo.83.12.1376","volume":"83","year":"1999","journal-title":"British Journal of Ophthalmology"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e31826218c7"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1097\/01.ico.0000154391.28254.1d"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1097\/01.ICL.0000092064.05514.04"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1002\/art.33389"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-013-0065-8"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2012.01.028"},{"issue":"2","key":"12","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1097\/ICO.0000000000000019","volume":"33","year":"2014","journal-title":"Cornea"}],"container-title":["Case Reports in Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crirh\/2014\/403452.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crirh\/2014\/403452.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crirh\/2014\/403452.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,22]],"date-time":"2017-06-22T11:03:23Z","timestamp":1498129403000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/crirh\/2014\/403452\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":12,"alternative-id":["403452","403452"],"URL":"https:\/\/doi.org\/10.1155\/2014\/403452","relation":{},"ISSN":["2090-6889","2090-6897"],"issn-type":[{"type":"print","value":"2090-6889"},{"type":"electronic","value":"2090-6897"}],"subject":[],"published":{"date-parts":[[2014]]}}}