{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T20:28:28Z","timestamp":1740169708485,"version":"3.37.3"},"reference-count":14,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/100007771","name":"Medical University of Silesia","doi-asserted-by":"crossref","award":["KNW-1-120\/10","KNW-1-115\/P\/1\/0"],"award-info":[{"award-number":["KNW-1-120\/10","KNW-1-115\/P\/1\/0"]}],"id":[{"id":"10.13039\/100007771","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100007771","name":"Medical University of Silesia","doi-asserted-by":"crossref","award":["KNW-1-120\/10","KNW-1-115\/P\/1\/0"],"award-info":[{"award-number":["KNW-1-120\/10","KNW-1-115\/P\/1\/0"]}],"id":[{"id":"10.13039\/100007771","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2014]]},"abstract":"We characterised a tissue factor (TF) and tissue factor pathway inhibitor (TFPI) expression in relation to severity of inflammatory infiltration of the gallbladder mucosa in a chronic cholecystitis. We prospectively studied the gallbladder specimens obtained from 54 patients who had undergone cholecystectomy due to chronic calculous cholecystitis and 16 calculosis-free gallbladder specimens obtained from patients who underwent cholecystectomy due to the polyp\/polyps as well as in cases of gallbladder injury. To assess TF and TFPI immunoreactivity by immunohistochemistry, the monoclonal anti-human TF and TFPI antibodies were used. The inflammatory infiltration of the gallbladder mucosa was reflected by the number of CD3 and CD68 positive cells. The expression of TF and TFPI differed significantly between the cholecystitis and the control group. Most capillary endothelial cells of the cholecystitis group presented weak expression for TFPI. The mean number of CD3 positive lymphocytes in the cholecystitis group was 18.6 \u00b1 12.2, but the mean number of CD68 positive cells was 29.7 \u00b1 13.9. In the control sections, it was 3.1 \u00b1 1.9 and 8.8 \u00b1 3.9, respectively (P<\/mml:mi><<\/mml:mo>0.001<\/mml:mn><\/mml:math>). The results of the current study suggest that the tissue procoagulant state found may be engaged in the etiopathogenesis of the cholecystitis.<\/jats:p>","DOI":"10.1155\/2014\/403639","type":"journal-article","created":{"date-parts":[[2014,3,3]],"date-time":"2014-03-03T07:57:16Z","timestamp":1393833436000},"page":"1-4","source":"Crossref","is-referenced-by-count":3,"title":["Tissue Factor and Tissue Factor Pathway Inhibitor in Chronically Inflamed Gallbladder Mucosa"],"prefix":"10.1155","volume":"2014","author":[{"given":"Jacek","family":"Liczko","sequence":"first","affiliation":[{"name":"Department of Histology and Embryology, Medical University of Silesia in Katowice, Jordana Street 19, 41-808 Zabrze, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0093-4172","authenticated-orcid":true,"given":"Tomasz","family":"Stawski","sequence":"additional","affiliation":[{"name":"Municipal Hospital, Che\u0142mo\u0144skiego Street 28, 43-600 Jaworzno, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ma\u0142gorzata","family":"\u017baba","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Medical University of Silesia in Katowice, Jordana Street 19, 41-808 Zabrze, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f3zef","family":"Kurek","sequence":"additional","affiliation":[{"name":"Municipal Hospital, Che\u0142mo\u0144skiego Street 28, 43-600 Jaworzno, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Sabat","sequence":"additional","affiliation":[{"name":"Department of Pathomorphology, Medical University of Silesia in Katowice, 3-go Maja Street 13-15, 41-800 Zabrze, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grzegorz","family":"Wyrobiec","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Medical University of Silesia in Katowice, 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