{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T20:13:51Z","timestamp":1790194431552,"version":"4.1.0"},"reference-count":88,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>Osteoarthritis (OA), a common musculoskeletal disorder, is projected to affect about 60 million people of total world population by 2020. The associated pain and disability impair the quality of life and also pose economic burden to the patient. Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely prescribed in OA, while diclofenac is the most prescribed one. Oral NSAIDs are not very patient friendly, as they cause various gastrointestinal adverse effects like bleeding, ulceration, and perforation. To enhance the tolerability of diclofenac and decrease the common side effects, aceclofenac (ACE) was developed by its chemical modification. As expected, ACE is more well-tolerated than diclofenac and possesses superior efficacy but is not completely devoid of the NSAID-tagged side effects. A series of chemical modifications of already planned drug is unjustified as it consumes quanta of time, efforts, and money, and this approach will also pose stringent regulatory challenges. Therefore, it is justified to deliver ACE employing tools of drug delivery and nanotechnology to refine its safety profile. The present review highlights the constraints related to the topical delivery of ACE and the various attempts made so far for the safe and effective topical delivery employing the novel materials and methods.<\/jats:p>","DOI":"10.1155\/2014\/406731","type":"journal-article","created":{"date-parts":[[2014,6,19]],"date-time":"2014-06-19T00:13:50Z","timestamp":1403136830000},"page":"1-11","source":"Crossref","is-referenced-by-count":83,"title":["Topical Delivery of Aceclofenac: Challenges and Promises of Novel Drug Delivery Systems"],"prefix":"10.1155","volume":"2014","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8159-8005","authenticated-orcid":true,"given":"Kaisar","family":"Raza","sequence":"first","affiliation":[{"name":"Department of Pharmacy, School of Chemical Sciences & Pharmacy, Central University of Rajasthan, Bandarsindri, Ajmer District, Rajasthan 305 801, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manish","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, School of Chemical Sciences & Pharmacy, Central University of Rajasthan, Bandarsindri, Ajmer District, Rajasthan 305 801, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pramod","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, School of Chemical Sciences & Pharmacy, Central University of Rajasthan, Bandarsindri, Ajmer District, Rajasthan 305 801, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruchi","family":"Malik","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, School of Chemical Sciences & Pharmacy, Central University of Rajasthan, Bandarsindri, Ajmer District, Rajasthan 305 801, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gajanand","family":"Sharma","sequence":"additional","affiliation":[{"name":"Division of Pharmaceutics, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160 014, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manmeet","family":"Kaur","sequence":"additional","affiliation":[{"name":"Division of Pharmaceutics, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160 014, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O. P.","family":"Katare","sequence":"additional","affiliation":[{"name":"Division of Pharmaceutics, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160 014, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"issue":"9","key":"1","first-page":"646","volume":"81","year":"2003","journal-title":"Bulletin of the World Health Organization"},{"issue":"4","key":"2","first-page":"766","volume":"24","year":"1997","journal-title":"Journal of Rheumatology"},{"issue":"1","key":"3","first-page":"3","volume":"41","year":"2002","journal-title":"Rheumatology"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2003.011742"},{"issue":"7128","key":"5","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1136\/bmj.316.7128.333","volume":"316","year":"1998","journal-title":"The British Medical Journal"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1185\/03007995.2011.649848"},{"key":"7","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/BF01983337","volume":"32","year":"1991","journal-title":"Agents and Actions Supplements"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1080\/03639040802277680"},{"key":"9","year":"2006"},{"issue":"1","key":"10","doi-asserted-by":"crossref","first-page":"113","DOI":"10.2165\/00003495-199652010-00008","volume":"52","year":"1996","journal-title":"Drugs"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.5.6.1347"},{"issue":"4","key":"12","first-page":"503","volume":"36","year":"1997","journal-title":"The British Journal of Rheumatology"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0536.2001.045003170.x"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1055\/s-2003-37627"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2006.01045.x"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2013-009217"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(97)10130-3"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1007\/s000110050752"},{"issue":"4","key":"19","first-page":"723","volume":"23","year":"1996","journal-title":"Journal of Rheumatology"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(00)00472-6"},{"issue":"2","key":"21","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/S0022-3565(24)38187-X","volume":"289","year":"1999","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"issue":"8","key":"22","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/PL00000261","volume":"50","year":"2001","journal-title":"Inflammation Research"},{"issue":"12","key":"23","first-page":"2692","volume":"28","year":"2001","journal-title":"Journal of Rheumatology"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1054\/jhsb.2001.0560"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1185\/03007995.2013.795139"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2010.10.013"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.38232.680567.EB"},{"issue":"3","key":"28","doi-asserted-by":"crossref","first-page":"555","DOI":"10.2165\/00003495-200060030-00004","volume":"60","year":"2000","journal-title":"Drugs"},{"issue":"2","key":"29","doi-asserted-by":"crossref","first-page":"31","DOI":"10.14227\/DT150208P31","volume":"15","year":"2008","journal-title":"Dissolution Technologies"},{"issue":"2","key":"30","first-page":"105","volume":"35","year":"2010","journal-title":"FABA Journal of Pharmaceutical Sciences"},{"issue":"5","key":"31","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1093\/chromsci\/46.5.440","volume":"46","year":"2008","journal-title":"Journal of Chromatographic Science"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-827X(02)01271-5"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1021\/cg301825u"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1007\/BF02207932"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.72451"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2013.08.019"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1023\/A:1016060403438"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1007\/s12272-010-1110-8"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1016\/S0928-0987(01)00167-1"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.3109\/02652048.2012.717115"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.3109\/10837450.2013.763260"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.3109\/1061186X.2012.761224"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2013.01.029"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2012.12.043"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1021\/mp300722f"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.3109\/03639045.2013.789051"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/498485"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/616810"},{"key":"49","doi-asserted-by":"publisher","DOI":"10.3109\/1061186X.2012.694887"},{"key":"50","doi-asserted-by":"publisher","DOI":"10.3109\/03639045.2011.602407"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.3109\/02652048.2010.546435"},{"key":"52","doi-asserted-by":"publisher","DOI":"10.3109\/1061186X.2010.499464"},{"key":"53","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2011.01452.x"},{"key":"54","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2010.09.003"},{"key":"55","doi-asserted-by":"publisher","DOI":"10.1016\/S0738-081X(01)00183-3"},{"key":"56","doi-asserted-by":"publisher","DOI":"10.3109\/09687688.2010.522203"},{"key":"57","first-page":"1025","volume":"9","year":"2014","journal-title":"International Journal of Nanomedicine"},{"issue":"1","key":"58","doi-asserted-by":"crossref","first-page":"52","DOI":"10.3390\/pharmaceutics6010052","volume":"6","year":"2014","journal-title":"Pharmaceutics"},{"key":"59","year":"2012","journal-title":"The American Pharmaceutical Review"},{"key":"60","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2012.09.006"},{"key":"61","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01538-08"},{"key":"62","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/480642"},{"key":"63","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2008.10.003"},{"issue":"4","key":"79","doi-asserted-by":"crossref","first-page":"618","DOI":"10.2165\/00003495-199346040-00004","volume":"46","year":"1993","journal-title":"Drugs"},{"issue":"2","key":"80","doi-asserted-by":"crossref","first-page":"223","DOI":"10.2165\/00003495-199447020-00002","volume":"47","year":"1994","journal-title":"Drugs"},{"key":"81","first-page":"1","volume-title":"Liposomes as a topical ocular drug delivery system","year":"1993"},{"key":"82","doi-asserted-by":"publisher","DOI":"10.1080\/02652040802055411"},{"key":"83","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevTherDrugCarrierSyst.v20.i1.20"},{"key":"66","doi-asserted-by":"publisher","DOI":"10.5138\/ijdd.2010.0975.0215.02016"},{"key":"67","doi-asserted-by":"publisher","DOI":"10.4103\/0250-474X.78524"},{"issue":"2","key":"68","first-page":"102","volume":"2","year":"2010","journal-title":"International Journal of Pharmacy and Pharmaceutical Sciences"},{"key":"84","doi-asserted-by":"publisher","DOI":"10.1166\/jbn.2007.008"},{"issue":"4","key":"69","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1007\/BF02976614","volume":"25","year":"2002","journal-title":"Archives of Pharmacal Research"},{"issue":"9","key":"70","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1007\/BF02977408","volume":"28","year":"2005","journal-title":"Archives of Pharmacal Research"},{"issue":"1","key":"71","doi-asserted-by":"crossref","first-page":"5","DOI":"10.18579\/jpcrkc\/2010\/9\/1\/79469","volume":"9","year":"2010","journal-title":"Iranian Journal of Pharmaceutical Research"},{"key":"72","doi-asserted-by":"publisher","DOI":"10.1208\/pt0804104"},{"key":"85","doi-asserted-by":"publisher","DOI":"10.1517\/17425247.2013.749234"},{"key":"86","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5173(94)90228-3"},{"key":"87","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-3659(97)00100-4"},{"issue":"3","key":"73","first-page":"87","volume":"5","year":"2010","journal-title":"Asian Journal of Pharmaceutical Sciences"},{"issue":"4","key":"74","first-page":"237","volume":"7","year":"2008","journal-title":"Iranian Journal of Pharmaceutical Research"},{"key":"75","doi-asserted-by":"publisher","DOI":"10.1163\/138577211X555721"},{"key":"76","doi-asserted-by":"publisher","DOI":"10.2174\/156720109787048320"},{"key":"88","doi-asserted-by":"publisher","DOI":"10.2174\/156720106778559010"},{"issue":"1","key":"77","volume":"2012","year":"2012","journal-title":"Inventi Impact: NDDS"},{"key":"64","doi-asserted-by":"publisher","DOI":"10.1208\/s12249-007-9028-2"},{"key":"89","doi-asserted-by":"publisher","DOI":"10.3797\/scipharm.1202-12"},{"key":"78","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2011.12.006"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2014\/406731.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2014\/406731.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2014\/406731.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,3]],"date-time":"2025-05-03T11:24:45Z","timestamp":1746271485000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/bmri\/2014\/406731\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":88,"alternative-id":["406731","406731"],"URL":"https:\/\/doi.org\/10.1155\/2014\/406731","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}