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Hypertension is associated with inflammation; however, whether inflammation is a cause or effect of hypertension is not well understood. The purpose of this review is to describe evidence from human and animal studies that inflammation leads to the development of hypertension, as well as the evidence for involvement of oxidative stress and endothelial dysfunction\u2014both thought to be key steps in the development of hypertension. Other potential proinflammatory conditions that contribute to hypertension\u2014such as activation of the sympathetic nervous system, aging, and elevated aldosterone\u2014are also discussed. Finally, we consider the potential benefit of anti-inflammatory drugs and statins for antihypertensive therapy. The evidence reviewed suggests that inflammation can lead to the development of hypertension and that oxidative stress and endothelial dysfunction are involved in the inflammatory cascade. Aging and aldosterone may also both be involved in inflammation and hypertension. Hence, in the absence of serious side effects, anti-inflammatory drugs could potentially be used to treat hypertension in the future.<\/jats:p>","DOI":"10.1155\/2014\/406960","type":"journal-article","created":{"date-parts":[[2014,7,20]],"date-time":"2014-07-20T17:03:53Z","timestamp":1405875833000},"page":"1-11","source":"Crossref","is-referenced-by-count":477,"title":["Roles of Inflammation, Oxidative Stress, and Vascular Dysfunction in Hypertension"],"prefix":"10.1155","volume":"2014","author":[{"given":"Quynh N.","family":"Dinh","sequence":"first","affiliation":[{"name":"Vascular Biology & Immunopharmacology Group, Department of Pharmacology, Monash University, Wellington Road, Clayton, VIC 3800, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grant R.","family":"Drummond","sequence":"additional","affiliation":[{"name":"Vascular Biology & Immunopharmacology Group, Department of Pharmacology, Monash University, Wellington Road, Clayton, VIC 3800, 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