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The model was induced by 3,3\u2032\u2010iminodipropionitrile (IDPN) treatment; then mice were divided into 4 groups (n=22, each); control and IDPN groups were gavaged with saline and the remaining 2 groups were gavaged with tiapride and JPZDD. We recorded the stereotypic behaviors of TS mice and measured the content of GABA in striatum by HPLC and GABA<jats:sub>A<\/jats:sub>R expression by immunohistochemistry and real\u2010time PCR. Our results showed that JPZDD inhibited the abnormal behaviors of TS model mice and decreased GABA levels and GABA<jats:sub>A<\/jats:sub>R protein and mRNA expression in the striatum of TS model mice. In brief, the mechanism by which JPZDD alleviates TS symptoms may be associated with GABA<jats:sub>A<\/jats:sub>R expression downregulation in striatum which may regulate GABA metabolism.<\/jats:p>","DOI":"10.1155\/2014\/407509","type":"journal-article","created":{"date-parts":[[2014,4,9]],"date-time":"2014-04-09T21:22:53Z","timestamp":1397078573000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Effect of \u201cJian\u2010Pi\u2010Zhi\u2010Dong Decoction\u201d on Gamma\u2010Aminobutyric Acid in a Mouse Model of Tourette Syndrome"],"prefix":"10.1155","volume":"2014","author":[{"given":"Wen","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjing","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1646-5406","authenticated-orcid":false,"given":"Daohan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minkyoung","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sumei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,4,9]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1875-9572(10)60050-2"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/08830738060210081001"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00787-011-0167-3"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2006.01.001"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1301528"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2009.05.015"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21809"},{"key":"e_1_2_8_8_2","article-title":"Erratum: European clinical guidelines for Tourette syndrome and other tic disorders, part II: pharmacological treatment, European Child and Adolescent Psychiatry, vol. 20, no. 4, pp. 173\u2013196, 2011","volume":"20","author":"Roessner V.","year":"2011","journal-title":"European Child and Adolescent Psychiatry"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1601-183X.2003.00037.x"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)11526-1"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.5582\/bst.2012.v6.4.212"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2011.01.026"},{"key":"e_1_2_8_13_2","first-page":"274","article-title":"Gamma-aminobutyric acid (GABA)","volume":"12","author":"Thorne Research Inc","year":"2007","journal-title":"Alternative Medicine Review"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aws104"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S6371"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-005-9024-4"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/385685"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfp043"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.3062"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2013.01.008"},{"key":"e_1_2_8_21_2","first-page":"1","article-title":"influence and mechanism of Jianpizhidong Decoction on autonomic activities in mouse model of Tourette\u2019s syndrome","volume":"18","author":"Cui X.","year":"2011","journal-title":"Journal of Beijing University of Traditional Chinese Medicine"},{"key":"e_1_2_8_22_2","first-page":"38","article-title":"Effects of Jianpizhidong Decoction on dopamine pathway in striatum of TS model mice","volume":"16","author":"Wei L.","year":"2009","journal-title":"Chinese Journal of Information on Traditional Chinese Medcine"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2011.03.003"},{"key":"e_1_2_8_24_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.278.5337.474"},{"key":"e_1_2_8_25_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-16-06063.2000"},{"key":"e_1_2_8_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2188"},{"key":"e_1_2_8_27_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0502624102"},{"key":"e_1_2_8_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.22206"},{"key":"e_1_2_8_29_2","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1002\/jnr.20108","article-title":"Extracellular taurine in the substantia nigra: Taurine-glutamate interaction","volume":"76","author":"Dopico J. 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