{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T12:50:52Z","timestamp":1760100652413,"version":"3.37.3"},"reference-count":40,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>Snake venom is composed of a mixture of substances that caused in victims a variety of pathophysiological effects. Besides antivenom, literature has described plants able to inhibit injuries and lethal activities induced by snake venoms. This work describes the inhibitory potential of ethanol, hexane, ethyl acetate, or dichloromethane extracts and fractions from stem and leaves of<jats:italic>Manilkara subsericea<\/jats:italic>against<jats:italic>in vivo<\/jats:italic>(hemorrhagic and edema) and<jats:italic>in vitro<\/jats:italic>(clotting, hemolysis, and proteolysis) activities caused by<jats:italic>Lachesis muta<\/jats:italic>venom. All the tested activities were totally or at least partially reduced by<jats:italic>M. subsericea<\/jats:italic>. However, when<jats:italic>L. muta<\/jats:italic>venom was injected into mice 15\u2009min first or after the materials, hemorrhage and edema were not inhibited. Thus,<jats:italic>M. subsericea<\/jats:italic>could be used as antivenom in snakebites of<jats:italic>L. muta<\/jats:italic>. And, this work also highlights Brazilian flora as a rich source of molecules with antivenom properties.<\/jats:p>","DOI":"10.1155\/2014\/408068","type":"journal-article","created":{"date-parts":[[2014,1,8]],"date-time":"2014-01-08T21:12:42Z","timestamp":1389215562000},"page":"1-7","source":"Crossref","is-referenced-by-count":14,"title":["Inhibitory Effect of Plant<i>Manilkara subsericea<\/i>against Biological Activities of<i>Lachesis muta<\/i>Snake Venom"],"prefix":"10.1155","volume":"2014","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6188-9921","authenticated-orcid":true,"given":"Eduardo Coriolano","family":"De Oliveira","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Venenos e Toxinas de Animais e Avalia\u00e7\u00e3o de Inibidores, Departamento de Biologia Celular e Molecular, Instituto de Biologia, Universidade Federal Fluminense, Outeiro de S\u00e3o Jo\u00e3o Batista, 3\u00ba andar, Sala 310, 24020-141 Niter\u00f3i, RJ, 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