{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T07:13:20Z","timestamp":1791357200672,"version":"4.3.1"},"reference-count":16,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Psychiatry"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>Valproic acid-induced hyperammonemic encephalopathy is a rare yet serious adverse drug reaction. Medication interactions such a valproic acid and topiramate can precipitate an event. We present the case of a 52-year-old female that presented with acute mental status change and hypersomnolence due to hyperammonemia caused by a valproic acid derivative. The patient improved after withdrawal of the offending medications and treatment with lactulose. Clinicians should remain hypervigilant in monitoring for valproic acid-induced hyperammonemic encephalopathy and risk factors such as polypharmacy.<\/jats:p>","DOI":"10.1155\/2014\/410403","type":"journal-article","created":{"date-parts":[[2014,7,17]],"date-time":"2014-07-17T21:06:58Z","timestamp":1405631218000},"page":"1-3","source":"Crossref","is-referenced-by-count":8,"title":["Hyperammonemic Encephalopathy due to Valproic Acid and Topiramate Interaction"],"prefix":"10.1155","volume":"2014","author":[{"given":"Jennifer D.","family":"Twilla","sequence":"first","affiliation":[{"name":"Methodist University Hospital, 1265 Union Avenue Memphis, TN 38104, USA"},{"name":"Department of Clinical Pharmacy, University of Tennessee Health Science Center, Memphis, TN 38163, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew S.","family":"Pierce","sequence":"additional","affiliation":[{"name":"Methodist University Hospital, 1265 Union Avenue Memphis, TN 38104, USA"},{"name":"Department of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"98","reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1176\/appi.ajp.159.1.1","volume":"159","year":"2002","journal-title":"The American Journal of Psychiatry"},{"issue":"8","key":"2","first-page":"1236","volume":"152","year":"1995","journal-title":"The American Journal of Psychiatry"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.genhosppsych.2011.12.009"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.2006.00655.x"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1345\/aph.19242"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1097\/00007691-198506000-00008"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1983.tb03428.x"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.54.1.230"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1097\/00004714-200212000-00019"},{"key":"10","year":"2014"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1023\/A:1021918104127"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.3122\/jabfm.2007.05.070062"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.164.7.1020"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-0186(02)00042-6"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1097\/WNF.0b013e3181ac3615"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1981.154"}],"container-title":["Case Reports in Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crips\/2014\/410403.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crips\/2014\/410403.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crips\/2014\/410403.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,22]],"date-time":"2017-06-22T16:55:43Z","timestamp":1498150543000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/crips\/2014\/410403\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":16,"alternative-id":["410403","410403"],"URL":"https:\/\/doi.org\/10.1155\/2014\/410403","relation":{},"ISSN":["2090-682X","2090-6838"],"issn-type":[{"value":"2090-682X","type":"print"},{"value":"2090-6838","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}