{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T05:58:31Z","timestamp":1791266311460,"version":"4.1.0"},"reference-count":61,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100002706","name":"AFA Insurance","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002706","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100007687","name":"Swedish Society of Medicine","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007687","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Swedish Cancer Society"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>\n                    <jats:italic>Background<\/jats:italic>\n                    . The distinction between malignant and benign pleural effusions is a diagnostic challenge today and measuring soluble biomarkers could add to the diagnostic accuracy. Syndecan-1 is a proteoglycan involved in various cellular functions and is cleaved from the cell surface in a regulated manner. The shed fragment, which can be recovered in effusion supernatant and in serum, retains its binding capacities, but often with different functions and signalling properties than the cell-bound form.\n                    <jats:italic>Aim<\/jats:italic>\n                    . This study aimed to investigate the diagnostic and prognostic value of soluble syndecan-1 in pleural effusions and sera from patients with pleural malignancies.\n                    <jats:italic>Study Design<\/jats:italic>\n                    . Using two cohorts of patients, we assessed the diagnostic and prognostic value of soluble syndecan-1 in pleural effusions and sera, using enzyme-linked immunosorbent assays.\n                    <jats:italic>Results<\/jats:italic>\n                    . In pleural effusions, syndecan-1 distinguished malignant and benign diseases, with an odds ratio of 8.59 (95% CI 3.67 to 20.09). Furthermore, syndecan-1 in pleural effusions predicted a survival difference for patients with pleural metastatic disease and malignant mesothelioma of 11.2 and 9.2 months, respectively. However, no such effects were seen when syndecan-1 was measured in serum.\n                    <jats:italic>Conclusion<\/jats:italic>\n                    . Soluble syndecan-1 is a promising candidate biomarker for the cytopathological diagnosis and prognostication of malignant pleural effusions.\n                  <\/jats:p>","DOI":"10.1155\/2014\/419853","type":"journal-article","created":{"date-parts":[[2014,7,24]],"date-time":"2014-07-24T17:58:17Z","timestamp":1406224697000},"page":"1-11","source":"Crossref","is-referenced-by-count":27,"title":["Diagnostic and Prognostic Value of Soluble Syndecan-1 in Pleural Malignancies"],"prefix":"10.1155","volume":"2014","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2396-8658","authenticated-orcid":true,"given":"Filip","family":"Mundt","sequence":"first","affiliation":[{"name":"Division of Pathology, Department of Laboratory Medicine, Karolinska Institutet, F46, Huddinge University Hospital, 141 86 Stockholm, 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