{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T04:25:40Z","timestamp":1773548740525,"version":"3.50.1"},"reference-count":50,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Ege University Research Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p><jats:italic>Aim<\/jats:italic>. Cathepsin C is the activator of the polymorphonuclear leukocyte-derived proteinase 3, which contributes to inflammatory processes. The aim of the present study was to investigate gingival crevicular fluid (GCF) proteinase 3 and cathepsin C levels in periodontal diseases.<jats:italic>Design<\/jats:italic>. Eighteen patients with chronic periodontitis (CP), 20 patients with generalized aggressive periodontitis (G-AgP), 20 patients with gingivitis, and 18 healthy subjects were included in the study. Periodontal parameters including probing depth, clinical attachment level, papilla bleeding index, and plaque index were assessed in all study subjects. GCF proteinase 3 and cathepsin C levels were analyzed by ELISA.<jats:italic>Results<\/jats:italic>. GCF proteinase 3 total amount was significantly higher in diseased groups compared to control group, after adjusting age<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mfenced separators=\"|\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:mrow><\/mml:mfenced><\/mml:mrow><\/mml:math>. No differences were found in GCF cathepsin C levels among the study groups<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:mfenced separators=\"|\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>&gt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:mrow><\/mml:mfenced><\/mml:mrow><\/mml:math>. Periodontal parameters of sampling sites were positively correlated with GCF proteinase 3 total amounts<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mrow><mml:mfenced separators=\"|\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.01<\/mml:mn><\/mml:mrow><\/mml:mfenced><\/mml:mrow><\/mml:math>but not with cathepsin C total amounts<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mrow><mml:mfenced separators=\"|\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>&gt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:mrow><\/mml:mfenced><\/mml:mrow><\/mml:math>.<jats:italic>Conclusions<\/jats:italic>. Elevated levels of GCF proteinase 3 in CP, G-AgP, and gingivitis might suggest that proteinase 3 plays a role during inflammatory periodontal events in host response. However, cathepsin C in GCF does not seem to have an effect on the pathogenesis of periodontal diseases.<\/jats:p>","DOI":"10.1155\/2014\/420830","type":"journal-article","created":{"date-parts":[[2014,5,19]],"date-time":"2014-05-19T21:11:53Z","timestamp":1400533913000},"page":"1-7","source":"Crossref","is-referenced-by-count":6,"title":["Are Proteinase 3 and Cathepsin C Enzymes Related to Pathogenesis of Periodontitis?"],"prefix":"10.1155","volume":"2014","author":[{"given":"Oya","family":"T\u00fcrko\u011flu","sequence":"first","affiliation":[{"name":"Department of Periodontology, School of Dentistry, Ege University, 35100 Izmir, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elif","family":"Azars\u0131z","sequence":"additional","affiliation":[{"name":"Department of Pediatric Immunology, School of Medicine, Ege University, 35100 Izmir, 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