{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:59:23Z","timestamp":1788872363319,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,12,11]],"date-time":"2014-12-11T00:00:00Z","timestamp":1418256000000},"content-version":"vor","delay-in-days":344,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Programa Multic\u00eantrico de P\u00f3s-gradua\u00e7\u00e3o em Ci\u00eancias Fisiol\u00f3gicas da Sociedade Brasileira de Fisiologia"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:p>\n                    <jats:italic>Kalanchoe pinnata<\/jats:italic>\n                    (KP) is popularly used for treating inflammatory diseases. This study investigated the antinociceptive, antiedematogenic, and anti\u2010inflammatory potential of the subcutaneous administration of KP flower aqueous extract (KPFE), its ethyl acetate (EtOAcF) and butanol (BuOHF) fractions, and the main KP flavonoid [quercetin 3\u2010\n                    <jats:italic>O<\/jats:italic>\n                    \u2010\n                    <jats:italic>\u03b1<\/jats:italic>\n                    \u2010L\u2010arabinopyranosyl (1 \u2192 2)\n                    <jats:italic>\u03b1<\/jats:italic>\n                    \u2010L\u2010rhamnopyranoside] (KPFV) in mice, as well as its possible mechanisms of action. KPFE (30\u2013300\u2009mg\/kg) and KPFV (1\u201310\u2009mg\/kg) inhibited the acetic acid\u2010induced writhing (ID\n                    <jats:sub>50<\/jats:sub>\n                    = 164.8 and 9.4\u2009mg\/kg, resp.). KPFE (300\u2009mg\/kg), EtOAcF (12\u2009mg\/kg), BuOHF (15\u2009mg\/kg), or KPFV (0.3\u20133.0\u2009mg\/kg) reduced leukocyte migration on carrageenan\u2010induced pleurisy (ID\n                    <jats:sub>50<\/jats:sub>\n                    = 2.0\u2009mg\/kg for KPFV). KPFE (3\u201330\u2009mg\/kg) and KPFV (0.3\u20133.0\u2009mg\/kg) reduced the croton oil\u2010induced ear edema (ID\n                    <jats:sub>50<\/jats:sub>\n                    = 4.3 and 0.76\u2009mg\/kg, resp.). KPFE and KPFV reduced the TNF\u2010\n                    <jats:italic>\u03b1<\/jats:italic>\n                    concentration in the pleural exudates on carrageenan\u2010induced pleurisy test. Moreover, KPFV inhibited COX\u20101 (IC\n                    <jats:sub>50<\/jats:sub>\n                    = 22.1\u2009\n                    <jats:italic>\u03bc<\/jats:italic>\n                    g\/mL) and COX\u20102 (IC\n                    <jats:sub>50<\/jats:sub>\n                    &gt; 50\u2009\n                    <jats:italic>\u03bc<\/jats:italic>\n                    g\/mL). The selectivity index (COX\u2010\/COX\u2010) was &lt;0.44. These results indicate that KPFE and KPFV produced antinociceptive, antiedematogenic, and anti\u2010inflammatory activities through COX inhibition and TNF\u2010\n                    <jats:italic>\u03b1<\/jats:italic>\n                    reduction, revealing that the main flavonoid in KP flowers and leaves plays an important role in the ethnomedicinal use of the plant.\n                  <\/jats:p>","DOI":"10.1155\/2014\/429256","type":"journal-article","created":{"date-parts":[[2014,12,11]],"date-time":"2014-12-11T16:02:25Z","timestamp":1418313745000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Mechanisms Underlying the Antinociceptive, Antiedematogenic, and Anti\u2010Inflammatory Activity of the Main Flavonoid from\n                    <i>Kalanchoe pinnata<\/i>"],"prefix":"10.1155","volume":"2014","author":[{"given":"Raquel Teixeira","family":"Ferreira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcela Ara\u00fajo Soares","family":"Coutinho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David do Carmo","family":"Malvar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elson Alves","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iziara Ferreira","family":"Florentino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00f4nia Soares","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederico Argollo","family":"Vanderlinde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,12,11]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2014.02.041"},{"key":"e_1_2_9_2_2","first-page":"51","article-title":"Anti-diabetic effect of Bryophyllum pinnatum leaves","volume":"8","author":"Aransiola E. F.","year":"2014","journal-title":"International Journal of Biological, Life Science and Engineering"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/1934578X0800301236"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.9734\/EJMP\/2014\/5901"},{"key":"e_1_2_9_5_2","first-page":"211","article-title":"Isolation and identification of substances with anti-hepatitis c virus activities from Kalanchoe pinnata","volume":"6","author":"Aoki C.","year":"2014","journal-title":"International Journal of Pharmacy and Pharmaceutical Sciences"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2011.06.030"},{"key":"e_1_2_9_7_2","first-page":"231","article-title":"Plantes m\u00e9dicinales africaines XXIV \u00e9tude de l\u2019action anti-inflammatoire de Bryophyllum pinnatum (Crassulaceae)","volume":"20","author":"Hema D.","year":"1986","journal-title":"Plantes M\u00e9dicinales et Phytoth\u00e9rapie"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2005.01.025"},{"key":"e_1_2_9_9_2","first-page":"60","article-title":"Preliminar study of the anti-inflammatory activity of Bryophillum calycinum Salisb","volume":"15","author":"Sousa P. J. C.","year":"2005","journal-title":"Revista Brasileira de Farmacognosia"},{"key":"e_1_2_9_10_2","first-page":"175","article-title":"Flowers from Kalanchoe pinnata are a rich source of T cell-suppressive flavonoids","volume":"7","author":"Coutinho M. A. S.","year":"2012","journal-title":"Natural Product Communications"},{"key":"e_1_2_9_11_2","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/S0031-6997(24)01472-8","article-title":"The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer","volume":"52","author":"Middleton E.","year":"2000","journal-title":"Pharmacological Reviews"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-981596"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2005.01.016"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1124\/mol.104.001206"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2003.06.036"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201200721"},{"key":"e_1_2_9_17_2","first-page":"51","article-title":"A propos de quelques produits usuels\u2014comparaison de deux m\u00e9thodes d\u2032\u00e9tude des analg\u00e9siques","volume":"11","author":"Vacher P. J.","year":"1964","journal-title":"Medicina Experimentalis"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0102-695X2011005000154"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2006.09.032"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2007.07.005"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2003.06.036"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0b013e32831394b8"},{"key":"e_1_2_9_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-007-7005-6"},{"key":"e_1_2_9_24_2","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.13.3.319-328.2006"},{"key":"e_1_2_9_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12272-010-1217-y"},{"key":"e_1_2_9_26_2","unstructured":"IchikawaM. OguraM. andIijimaT. Antiallergic flavone glycoside fromKalanchoe pinnatum JP Patent 1986 no. 61 118 396."},{"key":"e_1_2_9_27_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.180319297"},{"key":"e_1_2_9_28_2","doi-asserted-by":"publisher","DOI":"10.1248\/yakushi.127.1275"},{"key":"e_1_2_9_29_2","doi-asserted-by":"publisher","DOI":"10.1248\/yakushi.126.1171"},{"key":"e_1_2_9_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2012.02.003"},{"key":"e_1_2_9_31_2","doi-asserted-by":"publisher","DOI":"10.1006\/cyto.2000.0816"},{"key":"e_1_2_9_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201142231"},{"key":"e_1_2_9_33_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms140610926"},{"key":"e_1_2_9_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2012.03.013"},{"key":"e_1_2_9_35_2","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6882-13-195"},{"key":"e_1_2_9_36_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0089149"},{"key":"e_1_2_9_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2013.10.016"},{"key":"e_1_2_9_38_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-011-0385-7"},{"key":"e_1_2_9_39_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1270762"},{"key":"e_1_2_9_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2009.08.005"}],"container-title":["Evidence-Based Complementary and Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2014\/429256.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2014\/429256.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2014\/429256","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T20:57:35Z","timestamp":1747169855000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2014\/429256"}},"subtitle":[],"editor":[{"given":"Jae Youl","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,1]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["10.1155\/2014\/429256"],"URL":"https:\/\/doi.org\/10.1155\/2014\/429256","archive":["Portico"],"relation":{},"ISSN":["1741-427X","1741-4288"],"issn-type":[{"value":"1741-427X","type":"print"},{"value":"1741-4288","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1]]},"assertion":[{"value":"2014-07-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-11-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-12-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"429256"}}