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To identify the incidence of telomere attrition in SAA patients and investigate the relationship of telomere length with clinical parameters, SAA patients<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mo stretchy=\"false\">(<\/mml:mo><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">27<\/mml:mn><mml:mo stretchy=\"false\">)<\/mml:mo><\/mml:math>and healthy controls<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mo stretchy=\"false\">(<\/mml:mo><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">15<\/mml:mn><mml:mo stretchy=\"false\">)<\/mml:mo><\/mml:math>were enrolled in this study. Telomere length of PWBCs was significantly shorter in SAA patients than in controls. Analysis of gene expression of Shelterin complex revealed markedly low levels of<jats:italic>POT1<\/jats:italic>expression in SAA groups relative to controls. No differences in the gene expression of the other Shelterin components\u2014<jats:italic>TRF1<\/jats:italic>,<jats:italic>TRF2<\/jats:italic>,<jats:italic>TIN2<\/jats:italic>,<jats:italic>TPP1<\/jats:italic>, and<jats:italic>RAP1<\/jats:italic>\u2014were identified. Addition of IFN-<jats:italic><jats:italic>\u03b3<\/jats:italic><\/jats:italic>to culture media induced a similar fall in POT1 expression in bone marrow cells to that observed in cells cultured in the presence of SAA serum, suggesting IFN-<jats:italic><jats:italic>\u03b3<\/jats:italic><\/jats:italic>is the agent responsible for this effect of SAA serum. Furthermore, ATR, phosphorylated ATR, and phosphorylated ATM\/ATR substrate were all found similarly increased in bone marrow cells exposed to SAA serum, TNF-<jats:italic><jats:italic>\u03b1<\/jats:italic><\/jats:italic>, or IFN-<jats:italic><jats:italic>\u03b3<\/jats:italic><\/jats:italic>. In summary, SAA patients have short telomeres and decreased POT1 expression. TNF-<jats:italic><jats:italic>\u03b1<\/jats:italic><\/jats:italic>and IFN-<jats:italic><jats:italic>\u03b3<\/jats:italic><\/jats:italic>are found at high concentrations in SAA patients and may be the effectors that trigger apoptosis through POT1 and ATR.<\/jats:p>","DOI":"10.1155\/2014\/439530","type":"journal-article","created":{"date-parts":[[2014,5,6]],"date-time":"2014-05-06T21:07:59Z","timestamp":1399410479000},"page":"1-9","source":"Crossref","is-referenced-by-count":14,"title":["Expression of Shelterin Component<i>POT1<\/i>Is Associated with Decreased Telomere Length and Immunity Condition in Humans with Severe Aplastic Anemia"],"prefix":"10.1155","volume":"2014","author":[{"given":"Ting","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Hematology, General Hospital, Tianjin Medical University, 154 Anshandao, Heping, Tianjin 300052, 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