{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,3,29]],"date-time":"2023-03-29T05:51:32Z","timestamp":1680069092105},"reference-count":28,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Chronic myelogenous leukemia (CML) is characterized by tremendous amount of immature myeloid cells in the blood circulation. E2F1\u20133 and MYC are important transcription factors that form positive feedback loops by reciprocal regulation in their own transcription processes. Since genes regulated by E2F1\u20133 or MYC are related to cell proliferation and apoptosis, we wonder if there exists difference in the coexpression patterns of genes regulated concurrently by E2F1\u20133 and MYC between the normal and the CML states.<jats:italic>Results<\/jats:italic>. We proposed a method to explore the difference in the coexpression patterns of those candidate target genes between the normal and the CML groups. A disease-specific cutoff point for coexpression levels that classified the coexpressed gene pairs into strong and weak coexpression classes was identified. Our developed method effectively identified the coexpression pattern differences from the overall structure. Moreover, we found that genes related to the cell adhesion and angiogenesis properties were more likely to be coexpressed in the normal group when compared to the CML group.<jats:italic>Conclusion<\/jats:italic>. Our findings may be helpful in exploring the underlying mechanisms of CML and provide useful information in cancer treatment.<\/jats:p>","DOI":"10.1155\/2014\/439840","type":"journal-article","created":{"date-parts":[[2014,8,10]],"date-time":"2014-08-10T21:04:33Z","timestamp":1407704673000},"page":"1-7","source":"Crossref","is-referenced-by-count":5,"title":["Novel Approach for Coexpression Analysis of E2F1\u20133 and MYC Target Genes in Chronic Myelogenous Leukemia"],"prefix":"10.1155","volume":"2014","author":[{"given":"Fengfeng","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Health Technology and Informatics, Hong Kong Polytechnic University, Lee Shau Kee Building, Hung Hom, Kowloon, Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence W. C.","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Health Technology and Informatics, Hong Kong Polytechnic University, Lee Shau Kee Building, Hung Hom, Kowloon, Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William C. S.","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology, Queen Elizabeth Hospital, 30 Gascoigne Road, Kowloon, Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petrus","family":"Tang","sequence":"additional","affiliation":[{"name":"Bioinformatics Center, Chang Gung University, Taoyuan 333, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Yu","sequence":"additional","affiliation":[{"name":"Beijing Institute of Genomics, Chinese Academy of Sciences, Chaoyang District, Beijing 100029, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi-Ren","family":"Shyu","sequence":"additional","affiliation":[{"name":"Department of Computer Science, Informatics Institute, University of Missouri, Columbia, MO 65211, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy B. Y.","family":"Tsui","sequence":"additional","affiliation":[{"name":"Department of Health Technology and Informatics, Hong Kong Polytechnic University, Lee Shau Kee Building, Hung Hom, Kowloon, Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. C. Cesar","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Health Technology and Informatics, Hong Kong Polytechnic University, Lee Shau Kee Building, Hung Hom, Kowloon, Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parco M.","family":"Siu","sequence":"additional","affiliation":[{"name":"Department of Health Technology and Informatics, Hong Kong Polytechnic University, Lee Shau Kee Building, Hung Hom, Kowloon, Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. 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