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These improvements are linked to a deeper knowledge of the biology of disease and to the introduction in clinical practice of drugs with different mechanism of action such as proteasome inhibitors and immunomodulatory drugs (IMiDs). However, MM remains in most cases an incurable disease. For patients who relapse after treatment with novel agents, the prognosis is dismal and new drugs and therapeutic strategies are required for continued disease control. In this review, we summarize new insights in salvage therapy for relapsed\/refractory MM as emerging from recent clinical trials exploring the activity of bendamustine, new generation proteasome inhibitors, novel IMiDs, monoclonal antibodies, and drugs interfering with growth pathways.<\/jats:p>","DOI":"10.1155\/2014\/456037","type":"journal-article","created":{"date-parts":[[2014,5,19]],"date-time":"2014-05-19T17:12:56Z","timestamp":1400519576000},"page":"1-14","source":"Crossref","is-referenced-by-count":14,"title":["Salvage Therapy of Multiple Myeloma: The New Generation Drugs"],"prefix":"10.1155","volume":"2014","author":[{"given":"Alessandra","family":"Romano","sequence":"first","affiliation":[{"name":"Hematology Section, Department of Clinical and Molecular Biomedicine, University of Catania, Via Citelli 6, 95124 Catania, Italy"},{"name":"Fondazione Veronesi, Via Lancellotti 18, 00186 Roma, Italy"},{"name":"UOC di Ematologia con Trapianto di Midollo Osseo, Ospedale Ferrarotto, 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