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This study aimed to investigate the<jats:italic>in vitro<\/jats:italic>schistosomicidal activity of the crude extract (TV) and the essential oil (TV-EO) from the aerial parts of<jats:italic>T. vulgare<\/jats:italic>. TV-EO was obtained by hydrodistillation and analyzed by GC\/MS, which allowed the identification of<jats:italic>\u03b2<\/jats:italic>-thujone (84.13%) as the major constituent. TV and TV-EO, at 200\u2009<jats:italic>\u03bc<\/jats:italic>g\/mL, decreased motor activity and caused 100% mortality of all adult worms. At 100 and 50\u2009<jats:italic>\u03bc<\/jats:italic>g\/mL, only TV caused death of all adult worms, while TV-EO was inactive. TV (200\u2009<jats:italic>\u03bc<\/jats:italic>g\/mL) was also able to reduce viability and decrease production of developed eggs. Confocal laser scanning microscopy showed morphological alterations in the tegument of the<jats:italic>S. mansoni<\/jats:italic>surface after incubation with TV (50 and 100\u2009<jats:italic>\u03bc<\/jats:italic>g\/mL). Quantitative analysis on the schistosomes tegument showed that TV caused changes in the numbers of tubercles of<jats:italic>S. mansoni<\/jats:italic>male worms in a dose-dependent manner. The findings suggest that<jats:italic>T. vulgare<\/jats:italic>is a potential source of schistosomicidal compounds.<\/jats:p>","DOI":"10.1155\/2014\/460342","type":"journal-article","created":{"date-parts":[[2014,2,2]],"date-time":"2014-02-02T16:02:22Z","timestamp":1391356942000},"page":"1-9","source":"Crossref","is-referenced-by-count":45,"title":["Anthelmintic Activity of Crude Extract and Essential Oil of<i>Tanacetum vulgare<\/i>(Asteraceae) against Adult Worms of<i>Schistosoma mansoni<\/i>"],"prefix":"10.1155","volume":"2014","author":[{"given":"Loyana Silva","family":"Godinho","sequence":"first","affiliation":[{"name":"Faculdade de Farm\u00e1cia, Departamento de Ci\u00eancias Farmac\u00eauticas, Universidade Federal de Juiz de Fora, 36036-900 Juiz de Fora, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara Soares","family":"Aleixo de Carvalho","sequence":"additional","affiliation":[{"name":"Faculdade de Farm\u00e1cia, Departamento de Ci\u00eancias 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