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Trace elements participate in tissue and cellular and subcellular functions; these include immune regulation by humoral and cellular mechanisms, nerve conduction, muscle contractions, membrane potential regulations, and mitochondrial activity and enzyme reactions. The status of micronutrients such as iron and vanadium is higher in type 2 diabetes. The calcium, magnesium, sodium, chromium, cobalt, iodine, iron, selenium, manganese, and zinc seem to be low in type 2 diabetes while elements such as potassium and copper have no effect. In this review, we emphasized the status of macro and trace elements in type 2 diabetes and its advantages or disadvantages; this helps to understand the mechanism, progression, and prevention of type 2 diabetes due to the lack and deficiency of different macro and trace elements.<\/jats:p>","DOI":"10.1155\/2014\/461591","type":"journal-article","created":{"date-parts":[[2014,8,5]],"date-time":"2014-08-05T17:03:13Z","timestamp":1407258193000},"page":"1-9","source":"Crossref","is-referenced-by-count":103,"title":["Variation in Macro and Trace Elements in Progression of Type 2 Diabetes"],"prefix":"10.1155","volume":"2014","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4860-1262","authenticated-orcid":true,"given":"Khalid","family":"Siddiqui","sequence":"first","affiliation":[{"name":"Strategic Center for Diabetes Research, King Saud University, P.O. 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