{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T20:18:58Z","timestamp":1778703538343,"version":"3.51.4"},"reference-count":43,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pulmonary Medicine"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>A retrospective chart review study was performed to determine the presence of sleep disordered breathing (SDB) in children with primary mitochondrial disease (MD). The symptoms, sleep-related breathing, and movement abnormalities are described for 18 subjects (ages 1.5 to 18 years, 61% male) with MD who underwent polysomnography in our pediatric sleep center from 2007 to 2012. Of the 18 subjects with MD, the common indications for polysomnography were excessive somnolence or fatigue (61%,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mi>N<\/mml:mi><\/mml:mrow><\/mml:math>= 11), snoring (44%,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:mi>N<\/mml:mi><\/mml:mrow><\/mml:math>= 8), and sleep movement complaints (17%,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mrow><mml:mi>N<\/mml:mi><\/mml:mrow><\/mml:math>= 3). Polysomnographic measurements showed SDB in 56% (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mrow><mml:mi>N<\/mml:mi><\/mml:mrow><\/mml:math>= 10) (obstructive sleep apnea in 60% (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mrow><mml:mi>N<\/mml:mi><\/mml:mrow><\/mml:math>= 6), hypoxemia in 40% (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mrow><mml:mi>N<\/mml:mi><\/mml:mrow><\/mml:math>= 4), and sleep hypoventilation in 20% (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\"><mml:mrow><mml:mi>N<\/mml:mi><\/mml:mrow><\/mml:math>= 2)). There was a significant association between decreased muscle tone and SDB (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\"><mml:mrow><mml:mi>P<\/mml:mi><\/mml:mrow><\/mml:math>: 0.043) as well as obese and overweight status with SDB (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M9\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.036<\/mml:mn><\/mml:math>). SDB is common in subjects with MD. Early detection of SDB, utilizing polysomnography, should be considered to assist in identification of MD patients who may benefit from sleep-related interventions.<\/jats:p>","DOI":"10.1155\/2014\/467576","type":"journal-article","created":{"date-parts":[[2014,12,23]],"date-time":"2014-12-23T21:59:15Z","timestamp":1419371955000},"page":"1-8","source":"Crossref","is-referenced-by-count":12,"title":["Sleep Disordered Breathing in Children with Mitochondrial Disease"],"prefix":"10.1155","volume":"2014","author":[{"given":"Ricardo A.","family":"Mosquera","sequence":"first","affiliation":[{"name":"Department of Pediatrics, University of Texas Medical School, Houston, TX 77030, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary Kay","family":"Koenig","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Texas Medical School, Houston, TX 77030, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rahmat B.","family":"Adejumo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Texas Medical School, Houston, TX 77030, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2474-9169","authenticated-orcid":true,"given":"Justyna","family":"Chevallier","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Texas Medical School, Houston, TX 77030, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. Shahrukh","family":"Hashmi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Texas Medical School, Houston, TX 77030, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah E.","family":"Mitchell","sequence":"additional","affiliation":[{"name":"Memorial Hermann Memorial City Hospital, Pediatric Sleep Center, Houston, TX 77030, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan E.","family":"Pacheco","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Texas Medical School, Houston, TX 77030, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cindy","family":"Jon","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Texas Medical School, Houston, TX 77030, USA"},{"name":"Memorial Hermann Memorial City Hospital, Pediatric Sleep Center, Houston, TX 77030, 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