{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T05:15:21Z","timestamp":1773724521991,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61377001"],"award-info":[{"award-number":["61377001"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["CDJZR12 12 55 01"],"award-info":[{"award-number":["CDJZR12 12 55 01"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["10611201312011"],"award-info":[{"award-number":["10611201312011"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Central Universities","award":["61377001"],"award-info":[{"award-number":["61377001"]}]},{"name":"Central Universities","award":["CDJZR12 12 55 01"],"award-info":[{"award-number":["CDJZR12 12 55 01"]}]},{"name":"Central Universities","award":["10611201312011"],"award-info":[{"award-number":["10611201312011"]}]},{"name":"Central Universities","award":["61377001"],"award-info":[{"award-number":["61377001"]}]},{"name":"Central Universities","award":["CDJZR12 12 55 01"],"award-info":[{"award-number":["CDJZR12 12 55 01"]}]},{"name":"Central Universities","award":["10611201312011"],"award-info":[{"award-number":["10611201312011"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Computational and Mathematical Methods in Medicine"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>The treatment of cancer draws interest from researchers worldwide. Of the different extracts from traditional Chinese medicines, Tubeimoside 1 (TBMS 1) is regarded as an effective treatment for cancer. To determine the mechanism of TBMS 1, the shape\/pattern of HepG2 cells based on the microscopic imaging technology was determined to analyze experimental results; then the fluorescent spectra method was designed to investigate whether TBMS 1 affected HepG2 cells. A three-dimensional (3D) fluorescent spectra sweep was performed to determine the characteristic wave peak of HepG2 cells. A 2D fluorescent spectra method was then used to show the florescence change in HepG2 cells following treatment with TBMS 1. Finally, flow cytometry was employed to analyze the cell cycle of HepG2 cells. It was shown that TBMS 1 accelerated the death of HepG2 cells and had a strong dose- and time-dependent growth inhibitory effect on HepG2 cells, especially at the G2\/M phase. These results indicate that the fluorescent spectra method is a promising substitute for flow cytometry as it is rapid and cost-effective in HepG2 cells.<\/jats:p>","DOI":"10.1155\/2014\/470452","type":"journal-article","created":{"date-parts":[[2014,5,19]],"date-time":"2014-05-19T05:21:19Z","timestamp":1400476879000},"page":"1-7","source":"Crossref","is-referenced-by-count":6,"title":["Research on the Interaction between Tubeimoside 1 and HepG2 Cells Using the Microscopic Imaging and Fluorescent Spectra Method"],"prefix":"10.1155","volume":"2014","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9255-0672","authenticated-orcid":true,"given":"Xiaogang","family":"Lin","sequence":"first","affiliation":[{"name":"Key Laboratory of Optoelectronic Technology and Systems of Ministry of Education of China, Chongqing University, Chongqing 400044, China"}]},{"given":"Wenchao","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Optoelectronic Technology and Systems of Ministry of Education of China, Chongqing University, Chongqing 400044, China"}]},{"given":"Changbin","family":"Ye","sequence":"additional","affiliation":[{"name":"Key Laboratory of Optoelectronic Technology and Systems of Ministry of Education of China, Chongqing University, Chongqing 400044, China"}]},{"given":"Xiaozhu","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Optoelectronic Technology and Systems of Ministry of Education of China, Chongqing University, Chongqing 400044, China"}]},{"given":"Hao","family":"Zhu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Optoelectronic Technology and Systems of Ministry of Education of China, Chongqing University, Chongqing 400044, China"}]},{"given":"Wenbing","family":"Peng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Optoelectronic Technology and Systems of Ministry of Education of China, Chongqing University, Chongqing 400044, China"}]},{"given":"Jie","family":"Rong","sequence":"additional","affiliation":[{"name":"Key Laboratory of Optoelectronic Technology and Systems of Ministry of Education of China, Chongqing University, Chongqing 400044, China"}]}],"member":"311","reference":[{"issue":"4","key":"1","first-page":"346","volume":"21","year":"2002","journal-title":"Chinese Journal of Cancer"},{"issue":"5","key":"2","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1177\/000313489906500503","volume":"65","year":"1999","journal-title":"American Surgeon"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800830913"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1007\/s11604-012-0101-8"},{"issue":"4","key":"5","first-page":"484","volume":"73","year":"2010","journal-title":"Acta Gastro-Enterologica Belgica"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.03.196"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1097\/PPO.0b013e31816a6058"},{"issue":"3","key":"8","first-page":"191","volume":"2","year":"1995","journal-title":"Cancer Gene Therapy"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1126\/science.286.5439.531"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1038\/79519"},{"issue":"2","key":"11","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1038\/35101008","volume":"1","year":"2001","journal-title":"Nature Reviews Cancer"},{"issue":"4","key":"12","first-page":"729","volume":"17","year":"2000","journal-title":"International Journal of Oncology"},{"issue":"6","key":"15","first-page":"297","volume":"4","year":"2010","journal-title":"Bioscience Trends"},{"issue":"1","key":"13","first-page":"50","volume":"13","year":"2010","journal-title":"Current Opinion in Drug Discovery and Development"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1631\/jzus.2006.B1006"},{"issue":"5","key":"17","first-page":"314","volume":"4","year":"2010","journal-title":"Drug Discoveries & Therapeutics"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0b013e3181e6e398"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1007\/s10765-012-1256-3"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jprot.2011.08.014"},{"key":"21","first-page":"261","volume":"9","year":"2004","journal-title":"Chinese Journal of Clinic Pharmacology and Therapeutics"},{"key":"22","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1055\/s-2006-957831","volume":"62","year":"1996","journal-title":"Planta Medica"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.3788\/AOS20092905.1328"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2860(02)00256-9"}],"container-title":["Computational and Mathematical Methods in Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2014\/470452.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2014\/470452.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2014\/470452.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,13]],"date-time":"2023-07-13T06:28:01Z","timestamp":1689229681000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/cmmm\/2014\/470452\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":23,"alternative-id":["470452","470452"],"URL":"https:\/\/doi.org\/10.1155\/2014\/470452","relation":{},"ISSN":["1748-670X","1748-6718"],"issn-type":[{"value":"1748-670X","type":"print"},{"value":"1748-6718","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}