{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T09:08:29Z","timestamp":1790845709129,"version":"4.1.0"},"reference-count":57,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p><jats:italic>Aim<\/jats:italic>. The present investigation was designed to evaluate antiarthritic potential of fractions of hydroalcoholic extract from leaves of<jats:italic>P. alba<\/jats:italic>.<jats:italic>Materials and Methods<\/jats:italic>.<jats:italic>Plumeria alba<\/jats:italic>L. leaves were extracted with hydroalcohol (30\u2009:\u200970) to obtain hydroalcoholic extract of<jats:italic>P. alba<\/jats:italic>. This extract was further fractionated with solvents ethyl acetate and n-butanol to obtain EAPA and BPA, respectively. These fractions were tested against formaldehyde and Freund\u2019s complete adjuvant (FCA) induced arthritis. Arthritis assessment, paw volume, body weight, motor incoordination, and nociceptive threshold were measured. On day 21, the animals were sacrificed and histopathology was done.<jats:italic>Results<\/jats:italic>. The 100 and 200\u2009mg\/kg doses of EAPA and BPA caused a significant (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>\u2264<\/mml:mo><mml:mn fontstyle=\"italic\">0.05<\/mml:mn><mml:mtext>\u2013<\/mml:mtext><mml:mn fontstyle=\"italic\">0.01<\/mml:mn><\/mml:math>) reduction in paw swelling in both models. Erythrocyte sedimentation rate (ESR) and spleen weight decreased significantly (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.01<\/mml:mn><\/mml:math>) in arthritic rats treated with extracts. There was significant (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.05<\/mml:mn><\/mml:math>) improvement in thymus weight in EAPA treated rats whereas significant (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.01<\/mml:mn><\/mml:math>) improvement was also seen in haemoglobin level (Hb) in diclofenac treated group. Motor incoordination and nociceptive threshold were also significantly (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mi>P<\/mml:mi><mml:mo>\u2264<\/mml:mo><mml:mn fontstyle=\"italic\">0.05<\/mml:mn><mml:mtext>\u2013<\/mml:mtext><mml:mn fontstyle=\"italic\">0.01<\/mml:mn><\/mml:math>) improved.<jats:italic>Conclusion<\/jats:italic>. The present study suggests that<jats:italic>Plumeria alba<\/jats:italic>L. has protective activity against arthritis and supports the traditional use of<jats:italic>P. alba<\/jats:italic>for rheumatism and other inflammatory diseases.<\/jats:p>","DOI":"10.1155\/2014\/474616","type":"journal-article","created":{"date-parts":[[2014,6,16]],"date-time":"2014-06-16T21:35:39Z","timestamp":1402954539000},"page":"1-12","source":"Crossref","is-referenced-by-count":28,"title":["Investigation of Antiarthritic Potential of<i>Plumeria alba<\/i>L. Leaves in Acute and Chronic Models of Arthritis"],"prefix":"10.1155","volume":"2014","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0320-9382","authenticated-orcid":true,"given":"Manjusha","family":"Choudhary","sequence":"first","affiliation":[{"name":"Institute of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra, Haryana 136119, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vipin","family":"Kumar","sequence":"additional","affiliation":[{"name":"Institute of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra, Haryana 136119, India"},{"name":"Department of Pharmacy, School of Chemical Science and Pharmacy, Central University of Rajasthan, Ajmer 305801, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pankaj","family":"Gupta","sequence":"additional","affiliation":[{"name":"Dabur Research and Development Centre, Ghaziabad 201002, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Surender","family":"Singh","sequence":"additional","affiliation":[{"name":"All India Institute of Medical Sciences, New Delhi 110029, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2007.076430"},{"key":"2","year":"2006"},{"issue":"11","key":"3","first-page":"877","volume":"26","year":"1988","journal-title":"Indian Journal of Experimental Biology"},{"issue":"9","key":"4","first-page":"384","volume":"134","year":"2011","journal-title":"Indian Journal of Medical Research"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1002\/anr.1780321217"},{"key":"6","year":"1976"},{"key":"7","year":"2012"},{"key":"8","year":"1956"},{"key":"9","year":"1987"},{"key":"10","year":"2000"},{"key":"11","year":"1982"},{"key":"12","year":"1992"},{"key":"13","first-page":"677","volume":"60","year":"2006","journal-title":"Journal of Essential Oil"},{"key":"14","year":"2002"},{"key":"15","year":"1994"},{"key":"16","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/BF03048969","volume":"52","year":"1960","journal-title":"Proceedings of the Indian Academy of Science"},{"issue":"1","key":"17","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0031-9422(00)80071-0","volume":"22","year":"1983","journal-title":"Phytochemistry"},{"key":"18","year":"1996"},{"key":"19","year":"1984"},{"issue":"1","key":"20","first-page":"42","volume":"12","year":"2013","journal-title":"Chinese Journal of Integrative Medicine"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1016\/S1056-8719(00)00089-7"},{"key":"22","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1111\/j.1476-5381.1963.tb01508.x","volume":"21","year":"1963","journal-title":"British Journal of Pharmacology and Chemotherapy"},{"issue":"3","key":"23","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1076\/phbi.34.3.218.13205","volume":"34","year":"1996","journal-title":"International Journal of Pharmacognosy"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1590\/S1807-59322009000400015"},{"issue":"5","key":"25","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1159\/000230198","volume":"35","year":"1969","journal-title":"International Archives of Allergy and Applied Immunology"},{"issue":"4","key":"26","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1111\/j.2042-7158.1968.tb09743.x","volume":"20","year":"1968","journal-title":"Journal of Pharmacy and Pharmacology"},{"key":"27","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.jep.2004.01.003","volume":"91","year":"2004","journal-title":"Journal of Ethnopharmacology"},{"issue":"3","key":"28","first-page":"371","volume":"47","year":"1990","journal-title":"Pharmacology and Therapeutics"},{"key":"29","year":"1983"},{"key":"30","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/S0021-9258(18)76122-X","volume":"98","year":"1932","journal-title":"Journal of Biological Chemistry"},{"key":"31","volume-title":"Thrombosis and antithrombotic therapy","year":"1974"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200939578"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1016\/S1995-7645(12)60011-X"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-004-0871-3"},{"issue":"1","key":"35","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0022-3565(25)28953-4","volume":"178","year":"1971","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"key":"36","volume-title":"Antiarthritic and immunmodulatory activity","year":"2002"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2010.09.027"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.3736\/jcim20110415"},{"issue":"5","key":"39","first-page":"656","volume":"64","year":"1991","journal-title":"Laboratory Investigation"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1186\/ar2078"},{"issue":"4","key":"41","first-page":"473","volume":"58","year":"2006","journal-title":"Pharmacological Reports"},{"issue":"6","key":"42","first-page":"S71","volume":"19","year":"2001","journal-title":"Clinical and Experimental Rheumatology"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomag.2012.01.002"},{"key":"44","year":"1996"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2005.09.083"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.1016\/j.homp.2011.01.001"},{"issue":"6","key":"47","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.1172\/JCI117244","volume":"93","year":"1994","journal-title":"Journal of Clinical Investigation"},{"issue":"2","key":"48","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1002\/1529-0131(199604)9:2<151::AID-ANR1790090212>3.0.CO;2-#","volume":"9","year":"1996","journal-title":"Arthritis Care and Research"},{"key":"49","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780400320"},{"key":"50","year":"2006"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.1007\/BF01316493"},{"issue":"1","key":"52","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/0166-4328(87)90032-5","volume":"24","year":"1987","journal-title":"Behavioural Brain Research"},{"key":"53","year":"1963"},{"issue":"3","key":"54","first-page":"74","volume":"2","year":"2008","journal-title":"African Journal of Biochemistry Researchs"},{"key":"55","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2005.11.016"},{"issue":"3","key":"56","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1097\/00007632-199502000-00010","volume":"20","year":"1995","journal-title":"Spine"},{"key":"57","series-title":"A Text Book of Rheumatology","year":"1996"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2014\/474616.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2014\/474616.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2014\/474616.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,3]],"date-time":"2025-05-03T10:33:14Z","timestamp":1746268394000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/bmri\/2014\/474616\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":57,"alternative-id":["474616","474616"],"URL":"https:\/\/doi.org\/10.1155\/2014\/474616","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}