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Data were collected in the cities of Colonia Leopoldina, Novo Lino, and Uni\u00e3o dos Palmares, Alagoas state, from patients with cutaneous leishmaniasis (<jats:italic>Leishmania amazonensis<\/jats:italic>) who use medicinal plants to treat this disease. Plants extracts were tested at a concentration of 1\u2013100\u2009<jats:italic>\u03bc<\/jats:italic>g\/mL in all experiments, except in an assay to evaluate activity against amastigotes, when 10\u2009<jats:italic>\u03bc<\/jats:italic>g\/mL was used. All plants extracts did not show deleterious activity to the host cell evidenced by LDH assay at 100, 10, and 1\u2009<jats:italic>\u03bc<\/jats:italic>g\/mL after 48\u2009h of incubation. The plants extracts<jats:italic>Hyptis pectinata<\/jats:italic>(L.) Poit,<jats:italic>Aloe vera<\/jats:italic>L.,<jats:italic>Ruta graveolens<\/jats:italic>L.,<jats:italic>Pfaffia glomerata<\/jats:italic>(Spreng.) Pedersen, and<jats:italic>Chenopodium ambrosioides<\/jats:italic>L. exhibited direct activity against extracellular forms at 100\u2009<jats:italic>\u03bc<\/jats:italic>g\/mL; these extracts inhibited growth by 81.9%, 82.9%, 74.4%, 88.7%, and 87.4%, respectively, when compared with promastigotes. The plants extracts<jats:italic>H. pectinata, A. vera,<\/jats:italic>and<jats:italic>R. graveolens<\/jats:italic>also significantly diminished the number of amastigotes at 10\u2009<jats:italic>\u03bc<\/jats:italic>g\/mL, inhibiting growth by 85.0%, 40.4%, 94.2%, and 97.4%, respectively, when compared with control. Based on these data, we conclude that the five plants exhibited considerable leishmanicidal activity.<\/jats:p>","DOI":"10.1155\/2014\/478290","type":"journal-article","created":{"date-parts":[[2014,7,13]],"date-time":"2014-07-13T21:04:27Z","timestamp":1405285467000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Antileishmanial Activity of Medicinal Plants Used in Endemic Areas in Northeastern Brazil"],"prefix":"10.1155","volume":"2014","author":[{"given":"Aline Cavalcanti","family":"De Queiroz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thays de Lima Matos Freire","family":"Dias","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina Barbosa Brito","family":"Da Matta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiz Henrique Agra","family":"Cavalcante Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o Xavier","family":"de Ara\u00fajo-J\u00fanior","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Givanildo Bernardino de","family":"Ara\u00fajo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fl\u00e1via de Barros Prado","family":"Moura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magna Suzana","family":"Alexandre-Moreira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,7,13]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jprot.2009.12.012"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2007.08.003"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng2053"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0035671"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2009.12.016"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-007-0491-1"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2008.12.006"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.40.10.3572-3576.2002"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3156.2006.01695.x"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2005.08.015"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1590\/S1516-89132005000700009"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2004.07.002"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm9804073"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10719-006-9014-z"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1039\/b100455g"},{"key":"e_1_2_7_16_2","unstructured":"QuerozA. 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