{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T06:53:51Z","timestamp":1768632831906,"version":"3.49.0"},"reference-count":36,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Institute of Science and Technology"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Disease Markers"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Paraoxonase-1 (PON1) activity is suggested to be altered in individuals infected with human immunodeficiency virus type-1 (HIV-1). We investigated PON1 activity in individuals receiving different regimens of highly active antiretroviral therapy (HAART).<jats:italic>Methods<\/jats:italic>. PON1 activity was evaluated in 91 HIV-1 seronegative and 624 HIV-1 infected individuals (115 were not undergoing therapy (ART-na\u00efve), and 509 were receiving HAART). HIV-1 infected individuals were treated with the following: efavirenz (EFV;<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>195<\/mml:mn><\/mml:math>) or nevirapine (NVP;<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>95<\/mml:mn><\/mml:math>) or lopinavir\/ritonavir (LOP\/r;<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>219<\/mml:mn><\/mml:math>). Serum levels of total cholesterol (TC), HDL, and low-density lipoprotein (LDL) fractions and the atherogenic indices (AI, TC\u2009:\u2009HDL, and LDL\u2009:\u2009HDL ratios) were determined.<jats:italic>Results<\/jats:italic>. PON1 activity (U\/L) was lower in the ART-na\u00efve group compared with the other groups. PON1 activity correlated with CD4+ T-cell number of ART-na\u00efve group (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>r<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0,121<\/mml:mn><\/mml:math>;<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0,014<\/mml:mn><\/mml:math>). The LOP\/r group showed a reduction in HDL and an increase in AI (TC\u2009:\u2009HDL ratio) in comparison with other groups.<jats:italic>Conclusion<\/jats:italic>. PON1 activity was reduced in untreated individuals, but not in individuals receiving HAART. PON1 activity correlated with the number of CD4+ T-cells. The findings suggest that the activity of PON1 is associated with the immune status of HIV-1 infected individuals.<\/jats:p>","DOI":"10.1155\/2014\/480201","type":"journal-article","created":{"date-parts":[[2014,3,3]],"date-time":"2014-03-03T07:57:41Z","timestamp":1393833461000},"page":"1-7","source":"Crossref","is-referenced-by-count":8,"title":["Human Paraoxonase-1 Activity Is Related to the Number of CD4+ T-Cells and Is Restored by Antiretroviral Therapy in HIV-1-Infected Individuals"],"prefix":"10.1155","volume":"2014","author":[{"given":"Luciana Morganti Ferreira","family":"Maselli","sequence":"first","affiliation":[{"name":"Laboratory of Genetics and Molecular Hematology (LIM31), University of S\u00e3o Paulo School of Medicine, 05403-000 S\u00e3o Paulo, SP, Brazil"},{"name":"Research Division, Pr\u00f3-Sangue Hemocentro de S\u00e3o Paulo Foundation, 05403-000 S\u00e3o Paulo, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joel da","family":"Cunha","sequence":"additional","affiliation":[{"name":"Laboratory of Genetics and Molecular Hematology (LIM31), University of S\u00e3o Paulo School of Medicine, 05403-000 S\u00e3o Paulo, SP, Brazil"},{"name":"Department of Clinical Laboratory, Health Sciences Center, Federal University of Santa Catarina, 88040-900 Florian\u00f3polis, SC, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eliana Battaggia","family":"Gutierrez","sequence":"additional","affiliation":[{"name":"Clinics of Parasitic and Infectious Diseases, Hospital and Clinics of the University of S\u00e3o Paulo School of Medicine, 05403-000 S\u00e3o Paulo, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raul Cavalcante","family":"Maranh\u00e3o","sequence":"additional","affiliation":[{"name":"Lipid Metabolism Laboratory, Heart Institute, University of S\u00e3o Paulo School of Medicine, 05403-000 S\u00e3o Paulo, SP, 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