{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T05:47:00Z","timestamp":1777441620027,"version":"3.51.4"},"reference-count":50,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100004748","name":"Mashhad University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004748","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p><jats:italic>Aim.<\/jats:italic>To assess through a systematic review and meta-analysis of the literature the prognostic implication of sentinel lymph node mapping in Merkel cell carcinoma (MCC).<jats:italic>Materials and Methods.<\/jats:italic>PubMed and SCOPUS databases were searched by using \u201cMerkel AND sentinel\u201d as keywords. All studies with prognostic information regarding SLN mapping in cN0 MCC patients were included. Hazard ratio (HR) for overall survival (OS) and disease free survival (DFS) was used as effect size.<jats:italic>Results.<\/jats:italic>SLN biopsy predicted better DFS and OS as compared to the nodal observation in cN0 MCC patients (pooled HR for DFS: 1.61 (95% CI: 1.05\u20132.46),<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.028<\/mml:mn><\/mml:math>; pooled HR for OS: 1.08 (95% CI: 0.55\u20132.10),<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.8<\/mml:mn><\/mml:math>). Pathologically negative SLN (SLN\u2212) patients had better OS (pooled HR: 4.42 (95% CI: 1.82\u201310.7),<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.0009<\/mml:mn><\/mml:math>) and DFS (pooled HR: 2.58 (95% CI: 1.78\u20133.73)) as compared to SLN+ patients.<jats:italic>Conclusion.<\/jats:italic>SLN mapping can provide strong prognostic information regarding OS and DFS in cN0 MCC patients. More importantly, SLN mapping can improve DFS and possibly OS in cN0 MCC patients as compared to nodal observation. As MCC is a rare tumor, large multicenter prospective studies are still needed to validate the survival benefit of SLN mapping.<\/jats:p>","DOI":"10.1155\/2014\/489536","type":"journal-article","created":{"date-parts":[[2014,5,26]],"date-time":"2014-05-26T17:03:43Z","timestamp":1401123823000},"page":"1-9","source":"Crossref","is-referenced-by-count":34,"title":["Prognostic Significance of Sentinel Lymph Node Mapping in Merkel Cell Carcinoma: Systematic Review and Meta-Analysis of Prognostic Studies"],"prefix":"10.1155","volume":"2014","author":[{"given":"Ramin","family":"Sadeghi","sequence":"first","affiliation":[{"name":"Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad 9176699199, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zohreh","family":"Adinehpoor","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad 9176699199, 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