{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T21:03:19Z","timestamp":1740171799485,"version":"3.37.3"},"reference-count":28,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Disease Markers"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. The role of single preoperative serum CA-125 levels in predicting pelvic or paraaortic lymph node metastasis in patients operated for epithelial ovarian cancer has been investigated.<jats:italic>Methods<\/jats:italic>. 176 patients diagnosed with epithelial ovarian carcinoma after staging laparotomy between January 2002 and May 2010 were evaluated retrospectively.<jats:italic>Results<\/jats:italic>. The mean, geometric mean, and median of preoperative serum CA-125 levels were 632,6, 200,29, and 191,5\u2009U\/mL, respectively. The cut-off value predicting lymph node metastases in the ROC curve was 71,92\u2009U\/mL, which is significant in logistic regression analysis (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.005<\/mml:mn><\/mml:math>). The preoperative log CA-125 levels were also statistically significant in predicting lymph node metastasis in logistic regression analysis (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.008<\/mml:mn><\/mml:math>).<jats:italic>Conclusions<\/jats:italic>. The tumor marker CA-125, which increases with grade independent of the effect of stage in EOC, is predictive of lymph node metastasis with a high rate of false positivity in Turkish population. The high false positive rate may obscure the predictive value of CA-125.<\/jats:p>","DOI":"10.1155\/2014\/492537","type":"journal-article","created":{"date-parts":[[2014,3,25]],"date-time":"2014-03-25T17:01:50Z","timestamp":1395766910000},"page":"1-6","source":"Crossref","is-referenced-by-count":3,"title":["Can CA-125 Predict Lymph Node Metastasis in Epithelial Ovarian Cancers in Turkish Population?"],"prefix":"10.1155","volume":"2014","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4679-5446","authenticated-orcid":true,"given":"Sinem","family":"Sudolmu\u015f","sequence":"first","affiliation":[{"name":"Bezmialem Vak\u0131f \u00dcniversitesi, Adnan Menderes Bulvar\u0131 (Vatan Caddesi), Fatih, 34093 Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadiye","family":"K\u00f6ro\u011flu","sequence":"additional","affiliation":[{"name":"Bezmialem Vak\u0131f \u00dcniversitesi, Adnan Menderes Bulvar\u0131 (Vatan Caddesi), Fatih, 34093 Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00f6khan","family":"Y\u0131ld\u0131r\u0131m","sequence":"additional","affiliation":[{"name":"Kanuni Sultan Suleyman Research and Teaching Hospital, Atakent Mh. 1. Cd, K\u00fc\u00e7\u00fck\u00e7ekmece, 34303 Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Volkan","family":"\u00dclker","sequence":"additional","affiliation":[{"name":"Kanuni Sultan Suleyman Research and Teaching Hospital, Atakent Mh. 1. Cd, K\u00fc\u00e7\u00fck\u00e7ekmece, 34303 Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmet","family":"G\u00fclk\u0131l\u0131k","sequence":"additional","affiliation":[{"name":"Kanuni Sultan Suleyman Research and Teaching Hospital, Atakent Mh. 1. Cd, K\u00fc\u00e7\u00fck\u00e7ekmece, 34303 Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramazan","family":"Dansuk","sequence":"additional","affiliation":[{"name":"Bezmialem Vak\u0131f \u00dcniversitesi, Adnan Menderes Bulvar\u0131 (Vatan Caddesi), Fatih, 34093 Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"year":"2010","key":"1"},{"issue":"1","key":"2","first-page":"23","volume":"52","year":"2002","journal-title":"Ca: A Cancer Journal for Clinicians"},{"key":"3","first-page":"3","volume":"107","year":"2002","journal-title":"Cancer Treatment and Research"},{"doi-asserted-by":"publisher","key":"4","DOI":"10.1016\/S0020-7292(98)00234-3"},{"key":"5","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1002\/(SICI)1097-0142(19981015)83:8<1555::AID-CNCR10>3.0.CO;2-R","volume":"83","year":"1998","journal-title":"Cancer"},{"doi-asserted-by":"publisher","key":"6","DOI":"10.1111\/j.1525-1438.2007.00931.x"},{"doi-asserted-by":"publisher","key":"7","DOI":"10.1016\/S1072-7515(03)00234-5"},{"doi-asserted-by":"publisher","key":"8","DOI":"10.1006\/gyno.1996.0249"},{"doi-asserted-by":"publisher","key":"9","DOI":"10.1046\/j.1525-1438.2000.00053.x"},{"issue":"1","key":"10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/oxfordjournals.humrep.a136832","volume":"4","year":"1989","journal-title":"Human Reproduction"},{"doi-asserted-by":"publisher","key":"11","DOI":"10.1111\/j.1525-1438.2007.00912.x"},{"doi-asserted-by":"publisher","key":"12","DOI":"10.1080\/00016340802478158"},{"doi-asserted-by":"publisher","key":"13","DOI":"10.1016\/j.ejso.2009.01.005"},{"doi-asserted-by":"publisher","key":"14","DOI":"10.1080\/00016340601022777"},{"doi-asserted-by":"publisher","key":"15","DOI":"10.1016\/j.ejrad.2011.01.112"},{"doi-asserted-by":"publisher","key":"16","DOI":"10.1158\/1940-6207.CAPR-10-0402"},{"doi-asserted-by":"publisher","key":"17","DOI":"10.1016\/S0029-7844(02)02057-4"},{"doi-asserted-by":"publisher","key":"18","DOI":"10.2217\/bmm.09.21"},{"doi-asserted-by":"publisher","key":"19","DOI":"10.1073\/pnas.0914213107"},{"doi-asserted-by":"publisher","key":"20","DOI":"10.1158\/1940-6207.CAPR-10-0193"},{"doi-asserted-by":"publisher","key":"21","DOI":"10.1158\/1940-6207.CAPR-10-0195"},{"doi-asserted-by":"publisher","key":"22","DOI":"10.1136\/jclinpath-2012-201031"},{"doi-asserted-by":"publisher","key":"23","DOI":"10.2217\/17520363.1.4.513"},{"doi-asserted-by":"publisher","key":"24","DOI":"10.1016\/j.ejogrb.2008.08.011"},{"doi-asserted-by":"publisher","key":"25","DOI":"10.1007\/s12032-012-0447-x"},{"issue":"1","key":"26","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/1757-2215-6-31","volume":"6","year":"2013","journal-title":"Journal of Ovarian Research"},{"doi-asserted-by":"publisher","key":"27","DOI":"10.1097\/IGC.0b013e31828f7a24"},{"doi-asserted-by":"publisher","key":"28","DOI":"10.1186\/1757-2215-3-22"}],"container-title":["Disease Markers"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/dm\/2014\/492537.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/dm\/2014\/492537.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/dm\/2014\/492537.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,22]],"date-time":"2017-06-22T06:20:29Z","timestamp":1498112429000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/dm\/2014\/492537\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":28,"alternative-id":["492537","492537"],"URL":"https:\/\/doi.org\/10.1155\/2014\/492537","relation":{},"ISSN":["0278-0240","1875-8630"],"issn-type":[{"type":"print","value":"0278-0240"},{"type":"electronic","value":"1875-8630"}],"subject":[],"published":{"date-parts":[[2014]]}}}