{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T13:37:25Z","timestamp":1790689045869,"version":"4.1.0"},"reference-count":19,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,9,22]],"date-time":"2014-09-22T00:00:00Z","timestamp":1411344000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Veterinary Medicine"],"published-print":{"date-parts":[[2014,9,22]]},"abstract":"<jats:p>This study investigated the influence of 0.00584% hydrocortisone aceponate spray (HCA; Cortavance Virbac SA, Carros, France) on blood serum cortisol levels and peripheral blood CCR4<jats:sup>+<\/jats:sup>CD4<jats:sup>+<\/jats:sup>T-lymphocyte levels in dogs with atopic dermatitis. Patients were randomly divided into group I (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>N<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>8<\/mml:mn><\/mml:math>) and group II (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>N<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>8<\/mml:mn><\/mml:math>). The dogs in group I were sprayed with HCA on the affected skin once a day for three weeks. The dogs in group II were treated once a day for 3 days followed by no treatment for 4 days for a total of three weeks. For the dogs in group I and group II the CADESI-03 scores before and after use of HCA showed significant reduction (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.01<\/mml:mn><\/mml:math>). The postcortisol level after the use of HCA in group I showed 36.0% decrease and showed significant suppression (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.01<\/mml:mn><\/mml:math>). By comparison, the use of HCA on group II did not show decrease in postcortisol levels. There was a tendency of suppression for hypothalamus\u2014pituitary gland\u2014adrenal gland system, but it was not serious influence. In addition, there was no influence on peripheral blood CCR4<jats:sup>+<\/jats:sup>CD4<jats:sup>+<\/jats:sup>lymphocytes percentage in dogs in group I after treatment with HCA.<\/jats:p><jats:p><jats:ext-link ext-link-type=\"Corrigendum\"\/><jats:bold>Corrigendum to \u201cInfluence of a Diester Glucocorticoid Spray on the Cortisol Level and the CCR4<jats:sup>+<\/jats:sup>CD4<jats:sup>+<\/jats:sup>Lymphocytes in Dogs with Atopic Dermatitis: Open Study\u201d<\/jats:bold><jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"dx.doi.org\/10.1155\/2016\/6510347\"\/><\/jats:p>","DOI":"10.1155\/2014\/492735","type":"journal-article","created":{"date-parts":[[2014,9,22]],"date-time":"2014-09-22T21:01:27Z","timestamp":1411419687000},"page":"1-5","source":"Crossref","is-referenced-by-count":4,"title":["Influence of a Diester Glucocorticoid Spray on the Cortisol Level and the CCR4<sup>+<\/sup>CD4<sup>+<\/sup>Lymphocytes in Dogs with Atopic Dermatitis: Open Study"],"prefix":"10.1155","volume":"2014","author":[{"given":"Masato","family":"Fujimura","sequence":"first","affiliation":[{"name":"Fujimura Animal Allergy Hospital, Aomatanihigashi 5-10-26, Minou-shi, Osaka 562-0022, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1850-7526","authenticated-orcid":true,"given":"Hironobu","family":"Ishimaru","sequence":"additional","affiliation":[{"name":"Fujimura Animal Allergy Hospital, Aomatanihigashi 5-10-26, Minou-shi, Osaka 562-0022, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2010.00889.x"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.66.329"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.129.3.379"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.53.351"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200203010-00005"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.2165\/00063030-200013040-00005"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2009.00756.x"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2009.00782.x"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2009.00756.x"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2009.00758.x"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2007.00569.x"},{"key":"13","year":"2003"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2004.02039.x"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.70.989"},{"issue":"7","key":"16","doi-asserted-by":"crossref","first-page":"936","DOI":"10.2460\/ajvr.1979.40.07.936","volume":"40","year":"1979","journal-title":"American Journal of Veterinary Research"},{"issue":"5","key":"17","doi-asserted-by":"crossref","first-page":"716","DOI":"10.2460\/ajvr.1992.53.05.716","volume":"53","year":"1992","journal-title":"American Journal of Veterinary Research"},{"issue":"2","key":"18","doi-asserted-by":"crossref","first-page":"204","DOI":"10.2460\/ajvr.1982.43.02.204","volume":"43","year":"1982","journal-title":"The American Journal of Veterinary Research"},{"issue":"2","key":"19","first-page":"111","volume":"9","year":"2008","journal-title":"Veterinary Therapeutics"},{"issue":"6","key":"20","doi-asserted-by":"crossref","first-page":"685","DOI":"10.2460\/javma.1987.191.06.685","volume":"191","year":"1987","journal-title":"Journal of the American Veterinary Medical Association"}],"updated-by":[{"DOI":"10.1155\/2016\/6510347","type":"corrigendum","label":"Corrigendum","source":"publisher","updated":{"date-parts":[[2016,1,20]],"date-time":"2016-01-20T00:00:00Z","timestamp":1453248000000}}],"container-title":["Journal of Veterinary Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/archive\/2014\/492735.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/archive\/2014\/492735.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/archive\/2014\/492735.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,4]],"date-time":"2025-05-04T19:24:35Z","timestamp":1746386675000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/jvm\/2014\/492735\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9,22]]},"references-count":19,"alternative-id":["492735","492735"],"URL":"https:\/\/doi.org\/10.1155\/2014\/492735","relation":{},"ISSN":["2356-7708","2314-6966"],"issn-type":[{"value":"2356-7708","type":"print"},{"value":"2314-6966","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,22]]}}}