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Gels showed a maximum swelling ratio of 50 \u00b1 1.95 times of dried gel in PBS at pH 7.4. The swelling ratios increase in acidic and alkaline pH to 55.3 \u00b1 1.75 and 65.5 \u00b1 2.42, respectively. In the rheological test, prepared gels revealed viscoelastic properties and a small linear viscoelastic region of 0.166%. In vivo wound healing promoting activities of CDP gels containing 20\u2009<jats:italic>\u03bc<\/jats:italic>g\/mL EGF were evaluated on surgically induced dermal wounds in rats using pathologic examination. The application of CDP gel with incorporated EGF significantly reduced the defect on the rat\u2019s skin and enhanced epithelial healing compared with the topical application of the EGF-free CDP gel. The results clearly substantiate the beneficial effects of the topical application of CDP containing EGF in the acceleration of healthy wound healing process with less scarring.<\/jats:p>","DOI":"10.1155\/2014\/493732","type":"journal-article","created":{"date-parts":[[2014,7,8]],"date-time":"2014-07-08T18:12:46Z","timestamp":1404843166000},"page":"1-10","source":"Crossref","is-referenced-by-count":27,"title":["Healing Efficacy of an EGF Impregnated Triple Gel Based Wound Dressing: In Vitro and In Vivo Studies"],"prefix":"10.1155","volume":"2014","author":[{"given":"Najmeh","family":"Khanbanha","sequence":"first","affiliation":[{"name":"Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, P.O. 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