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But the changes in glucocorticoid receptor (GR) induced by acupuncture have not been detected clearly. The objective of the study was to observe the impacts of acupuncture on the protein expressions of corticotrophin releasing hormone (CRH), adrenocorticotropic hormone receptor (ACTHR), and GR under the physiological and stress states. The results showed that under the stress state, acupuncture upregulated the protein expression of GR in the hippocampus, hypothalamic paraventricular nucleus (PVN), and pituitary gland, downregulated the protein expression of GR in the adrenal cortex, and obviously reduced the protein expressions of CRH and ACTHR. Under the physiological state, acupuncture promoted GR protein expression in the hippocampus and CRH protein expression in the hippocampus and PVN. The results explained that acupuncture regulated the stress reaction via promoting the combination of glucocorticoids (GC) with GR, and GR protein expression. The increase of GR protein expression induced feedback inhibition on the overexpression of CRH and ACTHR,  likely decreased GC level, and caused the reduction of GR protein expression in the adrenal cortex.<\/jats:p>","DOI":"10.1155\/2014\/495379","type":"journal-article","created":{"date-parts":[[2014,3,11]],"date-time":"2014-03-11T21:01:52Z","timestamp":1394571712000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Acupuncture Relieves the Excessive Excitation of Hypothalamic\u2010Pituitary\u2010Adrenal Cortex Axis Function and Correlates with the Regulatory Mechanism of GR, CRH, and ACTHR"],"prefix":"10.1155","volume":"2014","author":[{"given":"Shao-Jun","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiao-Jiao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Li","family":"Qie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,3,11]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2013.09.034"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1042\/cs0940557"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4530(99)00045-1"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.146.5.929"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1080\/10253890802530730"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.npep.2005.03.001"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncpendmet0403"},{"key":"e_1_2_10_8_2","first-page":"52","article-title":"Effect of acupuncture at points \u201cbaihui taichong\u201d on the hypothalamic-pituitary-adrenocortical axis in the chronic mild unpredictable stressors depression rats","volume":"34","author":"Li L. 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