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Using immunoturbidimetry, we examined concentrations of beta2-microglobulin in cerebrospinal fluid in a large group of 6274 patients with defined neurological diseases. Cell counts, total protein, albumin, glucose, lactic acid, immunoglobulins concentrations, and isofocusing (IEF) were also evaluated. We found substantial changes of CSF<jats:italic>\u03b2<\/jats:italic>2-m concentrations in purulent meningitis, leptomeningeal metastasis, viral meningitis\/encephalitis, and neuroborreliosis, while in multiple sclerosis these changes were not significant. Intrathecal synthesis and immune activation were present in these clinical entities. A new normative study enables better understanding of beta2-microglobulin behavior in CSF.<\/jats:p>","DOI":"10.1155\/2014\/495402","type":"journal-article","created":{"date-parts":[[2014,5,8]],"date-time":"2014-05-08T21:20:18Z","timestamp":1399584018000},"page":"1-6","source":"Crossref","is-referenced-by-count":36,"title":["Beta2-Microglobulin as a Diagnostic Marker in Cerebrospinal Fluid: A Follow-Up Study"],"prefix":"10.1155","volume":"2014","author":[{"given":"Jana","family":"Svato\u0148ov\u00e1","sequence":"first","affiliation":[{"name":"Department of Neurology, RHG City Hospital, Mostn\u00ed 934, 278 01 Kralupy nad Vltavou, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kl\u00e1ra","family":"Bo\u0159eck\u00e1","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Thomayer Hospital, V\u00edde\u0148sk\u00e1 800, 140 00 Prague, Czech 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