{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:57:33Z","timestamp":1789001853279,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["K23AI07759"],"award-info":[{"award-number":["K23AI07759"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Infectious Diseases in Obstetrics and Gynecology"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p><jats:italic>Background.<\/jats:italic>HIV-infected adolescents may be at higher risk for high-grade cervical lesions than HIV-uninfected adolescents. The purpose of this study was to compare the prevalence of high-risk HPV (HR-HPV) infections and Pap smear abnormalities between these two groups.<jats:italic>Methods.<\/jats:italic>In this cross-sectional study, we compared the HPV DNA and Pap smear results between 35 HIV-infected and 50 HIV-uninfected adolescents in order to determine the prevalence of HR-HPV genotypes and cervical cytological abnormalities. Comparisons were made using Pearson<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:msup><mml:mrow><mml:mi>\u03c7<\/mml:mi><\/mml:mrow><mml:mrow><mml:mn>2<\/mml:mn><\/mml:mrow><\/mml:msup><\/mml:mrow><\/mml:math>and independent-samples<jats:italic>t<\/jats:italic>-tests analyses, and associations between demographic and behavioral characteristics and HPV infections were examined.<jats:italic>Results.<\/jats:italic>HIV-infected participants were more likely to be infected with any HPV (88.6% versus 48.0%;<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>) and with at least one HR-HPV (60.0% versus 24.0%;<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>), and to have multiple concurrent HPV infections (68.6% versus 22.0%;<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>). HPV 16 and 18 were relatively underrepresented among HR-HPV infections. Abnormal Pap test results were more common among HIV-infected participants (28.8% versus 12.0%;<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.054<\/mml:mn><\/mml:math>). A history of smoking was associated with HR-HPV infection.<jats:italic>Conclusions.<\/jats:italic>HIV-infected adolescents have an increased risk of infection with HR-HPV and of Pap test abnormalities. The majority of HR-HPV infections among our participants would not be prevented by the currently available vaccinations against HPV.<\/jats:p>","DOI":"10.1155\/2014\/498048","type":"journal-article","created":{"date-parts":[[2014,10,20]],"date-time":"2014-10-20T17:04:27Z","timestamp":1413824667000},"page":"1-6","source":"Crossref","is-referenced-by-count":30,"title":["Cervical Dysplasia and High-Risk Human Papillomavirus Infections among HIV-Infected and HIV-Uninfected Adolescent Females in South Africa"],"prefix":"10.1155","volume":"2014","author":[{"given":"David H.","family":"Adler","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine, University of Rochester, 601 Elmwood Avenue, P.O. 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Box 655, Rochester, NY 14642, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracy L.","family":"Meiring","sequence":"additional","affiliation":[{"name":"Institute of Infectious Diseases & Molecular Medicine and Division of Medical Virology, Faculty of Health Sciences, University of Cape Town, Anzio Road, Observatory, Cape Town, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna-Lise","family":"Williamson","sequence":"additional","affiliation":[{"name":"Institute of Infectious Diseases & Molecular Medicine and Division of Medical Virology, Faculty of Health Sciences, University of Cape Town, Anzio Road, Observatory, Cape Town, South Africa"},{"name":"National Health Laboratory Service, Groote Schuur Hospital, Cape Town, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda-Gail","family":"Bekker","sequence":"additional","affiliation":[{"name":"Desmond Tutu HIV Centre, Institute of Infectious Diseases & Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Anzio Road, Observatory, Cape Town, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.55.4.244"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2013.10.002"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1993.0350006002300"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3156.2009.02372.x"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0072094"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2012.06.045"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1097\/00126334-200108150-00003"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199711063371903"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1155\/S1064744902000029"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3182054cae"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPTGD94EVRSJCG"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-156-12-201206190-00424"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/931281"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(09)70096-8"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1001\/jama.287.16.2114"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2014.00048"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.21166"},{"issue":"51-52","key":"19","first-page":"1038","volume":"61","year":"2013","journal-title":"Morbidity and Mortality Weekly Report"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1097\/IGC.0b013e3182094d78"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2004.12.003"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1097\/00126334-200212150-00014"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1086\/424466"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.5664"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(01)00780-X"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.27790"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.4172\/2329-9541.1000113"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/91.3.226"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(00)00948-0"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2003.10.004"}],"container-title":["Infectious Diseases in Obstetrics and Gynecology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/idog\/2014\/498048.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/idog\/2014\/498048.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/idog\/2014\/498048.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2016,8,18]],"date-time":"2016-08-18T14:12:28Z","timestamp":1471529548000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/idog\/2014\/498048\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":29,"alternative-id":["498048","498048"],"URL":"https:\/\/doi.org\/10.1155\/2014\/498048","relation":{},"ISSN":["1064-7449","1098-0997"],"issn-type":[{"value":"1064-7449","type":"print"},{"value":"1098-0997","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}