{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T06:26:01Z","timestamp":1782282361676,"version":"3.54.5"},"reference-count":57,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003758","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa e Desenvolvimento Cient\u00edfico do Maranh\u00e3o","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003758","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Funda\u00e7\u00e3o de Amparo \u00e1 Pesquisa do Estado de S\u00e3o Paulo"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>Thousands of people suffer from severe malaria every year. The innate immune response plays a determinant role in host\u2019s defence to malaria. Transient receptor potential vanilloid 1 (TRPV1) modulates macrophage-mediated responses in sepsis, but its role in other pathogenic diseases has never been addressed. We investigated the effects of capsazepine, a TRPV1 antagonist, in malaria. C57BL\/6 mice received 10<jats:sup>5<\/jats:sup>red blood cells infected with<jats:italic>Plasmodium berghei<\/jats:italic>ANKA intraperitoneally. Noninfected mice were used as controls. Capsazepine or vehicle was given intraperitoneally for 6 days. Mice were culled on day 7 after infection and blood and spleen cell phenotype and activation were evaluated. Capsazepine decreased circulating but not spleen F4\/80<jats:sup>+<\/jats:sup>Ly6G<jats:sup>+<\/jats:sup>cell numbers as well as activation of both F4\/80<jats:sup>+<\/jats:sup>and F4\/80<jats:sup>+<\/jats:sup>Ly6G<jats:sup>+<\/jats:sup>cells in infected animals. In addition, capsazepine increased circulating but not spleen GR1<jats:sup>+<\/jats:sup>and natural killer (NK) population, without interfering with natural killer T (NKT) cell numbers and blood NK and NKT activation. However, capsazepine diminished CD69 expression in spleen NKT but not NK cells. Infection increased lipid peroxidation and the release of TNF<jats:italic>\u03b1<\/jats:italic>and IFN<jats:italic>\u03b3<\/jats:italic>, although capsazepine-treated group exhibited lower levels of lipid peroxidation and TNF<jats:italic>\u03b1<\/jats:italic>. Capsazepine treatment did not affect parasitaemia. Overall, TRPV1 antagonism modulates the innate immune response to malaria.<\/jats:p>","DOI":"10.1155\/2014\/506450","type":"journal-article","created":{"date-parts":[[2014,8,24]],"date-time":"2014-08-24T17:02:38Z","timestamp":1408899758000},"page":"1-12","source":"Crossref","is-referenced-by-count":20,"title":["TRPV1 Antagonism by Capsazepine Modulates Innate Immune Response in Mice Infected with<i>Plasmodium berghei<\/i>ANKA"],"prefix":"10.1155","volume":"2014","author":[{"given":"Elizabeth S.","family":"Fernandes","sequence":"first","affiliation":[{"name":"Universidade CEUMA, 65075-120 S\u00e3o Lu\u00eds, MA, Brazil"},{"name":"Cardiovascular Division, King\u2019s College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina X. 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