{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T00:16:52Z","timestamp":1780100212694,"version":"3.54.0"},"reference-count":29,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100004625","name":"Universiti Teknologi MARA","doi-asserted-by":"publisher","award":["RAGS: 600-RMI\/RAGS 5\/3"],"award-info":[{"award-number":["RAGS: 600-RMI\/RAGS 5\/3"]}],"id":[{"id":"10.13039\/501100004625","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>Watermelon is a natural product that contains high level of antioxidants and may prevent oxidative damage in tissues due to free radical generation following an exposure to ionizing radiation. The present study aimed to investigate the radioprotective effects of watermelon (<jats:italic>Citrullus lanatus<\/jats:italic>(Thunb.) Matsum. and Nakai) juice against oxidative damage induced by low dose X-ray exposure in mice. Twelve adult male ICR mice were randomly divided into two groups consisting of radiation (Rx) and supplementation (Tx) groups. Rx received filtered tap water, while Tx was supplemented with 50% (v\/v) watermelon juice for 28 days<jats:italic>ad libitum<\/jats:italic>prior to total body irradiation by 100\u2009<jats:italic>\u03bc<\/jats:italic>Gy X-ray on day 29. Brain, lung, and liver tissues were assessed for the levels of malondialdehyde (MDA), apurinic\/apyrimidinic (AP) sites, glutathione (GSH), and superoxide dismutase (SOD) inhibition activities. Results showed significant reduction of MDA levels and AP sites formation of Tx compared to Rx<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mo stretchy=\"false\">(<\/mml:mo><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><mml:mo stretchy=\"false\">)<\/mml:mo><\/mml:math>. Mice supplemented with 50% watermelon juice restore the intracellular antioxidant activities by significantly increased SOD inhibition activities and GSH levels compared to Rx. These findings may postulate that supplementation of 50% watermelon (<jats:italic>Citrullus lanatus<\/jats:italic>(Thunb.) Matsum. and Nakai) juice could modulate oxidative damage induced by low dose X-ray exposure.<\/jats:p>","DOI":"10.1155\/2014\/512834","type":"journal-article","created":{"date-parts":[[2014,4,29]],"date-time":"2014-04-29T17:07:29Z","timestamp":1398791249000},"page":"1-6","source":"Crossref","is-referenced-by-count":19,"title":["Watermelon (<i>Citrullus lanatus<\/i>(Thunb.) Matsum. and Nakai) Juice Modulates Oxidative Damage Induced by Low Dose X-Ray in Mice"],"prefix":"10.1155","volume":"2014","author":[{"given":"Mohd Khairul Amran","family":"Mohammad","sequence":"first","affiliation":[{"name":"Department of Medical Laboratory Technology, Faculty of Health Sciences, Universiti Teknologi MARA, UiTM Puncak Alam, 42300 Bandar Puncak Alam, Selangor, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhamad Idham","family":"Mohamed","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Technology, Faculty of Health Sciences, Universiti Teknologi MARA, UiTM Puncak Alam, 42300 Bandar Puncak Alam, Selangor, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8710-0685","authenticated-orcid":true,"given":"Ainul Mardhiyah","family":"Zakaria","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Technology, Faculty of Health Sciences, Universiti Teknologi MARA, UiTM Puncak Alam, 42300 Bandar Puncak Alam, Selangor, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hairil Rashmizal","family":"Abdul Razak","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging, Faculty of Health Sciences, Universiti Teknologi MARA, UiTM Puncak Alam, 42300 Bandar Puncak Alam, Selangor, Selangor, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan Mazlina Md.","family":"Saad","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Technology, Faculty of Health Sciences, Universiti Teknologi MARA, UiTM Puncak Alam, 42300 Bandar Puncak Alam, Selangor, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.5897\/AJB11.756"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2006.07.001"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2005.12.009"},{"issue":"7","key":"4","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1590\/S0100-879X2005000700003","volume":"38","year":"2005","journal-title":"Brazilian Journal of Medical and Biological Research"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2009.05.004"},{"issue":"1","key":"6","first-page":"29","volume":"51","year":"2013","journal-title":"Indian Journal of Experimental Biology"},{"issue":"5","key":"7","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1667\/RR3042.2","volume":"178","year":"2012","journal-title":"Radiation Research"},{"issue":"2","key":"8","first-page":"181","volume":"53","year":"2009","journal-title":"Indian Journal of Physiology and Pharmacology"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.4297\/najms.2011.3268"},{"issue":"5","key":"10","first-page":"300","volume":"40","year":"2003","journal-title":"Indian Journal of Biochemistry and Biophysics"},{"key":"11","first-page":"794","volume":"52","year":"2004","journal-title":"Journal of Association of Physicians of India"},{"issue":"6","key":"12","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/S0300-9084(81)80088-0","volume":"63","year":"1981","journal-title":"Biochimie"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2010.03.008"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2012.01.016"},{"issue":"5","key":"15","doi-asserted-by":"crossref","first-page":"704","DOI":"10.21273\/JASHS.129.5.0704","volume":"129","year":"2004","journal-title":"Journal of the American Society for Horticultural Science"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2006.11.008"},{"key":"17","volume":"3, article 145","year":"2012","journal-title":"Journal of Cytology and Histology"},{"issue":"4","key":"18","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1177\/147323001103900412","volume":"39","year":"2011","journal-title":"Journal of International Medical Research"},{"issue":"2","key":"19","first-page":"198","volume":"10","year":"2014","journal-title":"World Journal of Medical Sciences"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2007.01.012"},{"issue":"4","key":"21","first-page":"2090","volume":"10","year":"2011","journal-title":"Electronic Journal of Environmental, Agricultural and Food Chemistry"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1007\/s00334-004-0039-6"},{"issue":"9","key":"23","doi-asserted-by":"crossref","first-page":"2433","DOI":"10.1016\/j.fct.2011.06.064","volume":"49","year":"2011","journal-title":"Food and Chemical Toxicology"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-483X(02)00448-1"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1016\/S0921-8777(01)00063-5"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/980480"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1002\/jsfa.4250"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1002\/jsfa.880"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.3253"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2014\/512834.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2014\/512834.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2014\/512834.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,9]],"date-time":"2019-08-09T20:32:44Z","timestamp":1565382764000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/bmri\/2014\/512834\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":29,"alternative-id":["512834","512834"],"URL":"https:\/\/doi.org\/10.1155\/2014\/512834","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}