{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T03:50:14Z","timestamp":1772164214872,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100003062","name":"Erciyes University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003062","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Endocrinology"],"published-print":{"date-parts":[[2014]]},"abstract":"\n Sheehan\u2019s Syndrome (SS) is defined as pituitary hormone deficiency due to ischemic infarction of the pituitary gland as a result of massive postpartum uterine hemorrhage. Herein, we aimed to investigate the roles of\n Factor II<\/jats:italic>\n (G20210A),\n Factor V<\/jats:italic>\n (G1691A),\n MTHFR<\/jats:italic>\n (C677T and A1298C),\n PAI-1<\/jats:italic>\n 4G\/5G, and\n \n TNF-\n \u03b1<\/jats:italic>\n <\/jats:italic>\n (\n \n -<\/mml:mo>\n 308<\/mml:mn>\n \u2009<\/mml:mo>\n \u2009<\/mml:mo>\n G<\/mml:mtext>\n ><\/mml:mo>\n A<\/mml:mtext>\n <\/mml:math>\n ) gene polymorphisms in the etiopathogenesis of SS. Venous blood samples were obtained from 53 cases with SS and 43 healthy women. Standard methods were used to extract the genomic DNAs.\n Factor II<\/jats:italic>\n (G20210A),\n Factor V<\/jats:italic>\n (G1691A), and\n MTHFR<\/jats:italic>\n (C677T and A1298C) polymorphisms were identified by real-time PCR.\n PAI-1<\/jats:italic>\n 4G\/5G and\n \n TNF-\n \u03b1<\/jats:italic>\n <\/jats:italic>\n (\n \n -<\/mml:mo>\n 308<\/mml:mn>\n \u2009<\/mml:mo>\n \u2009<\/mml:mo>\n G<\/mml:mtext>\n ><\/mml:mo>\n A<\/mml:mtext>\n <\/mml:math>\n ) gene polymorphisms were detected with polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) methods. According to statistical analysis, none of the polymorphisms were found to be significantly higher in the SS group compared to the control group. Hence, we suggest that genetic factors other than\n Factor II, Factor V, MTHFR, PAI-1<\/jats:italic>\n , and\n \n TNF-\n \u03b1<\/jats:italic>\n <\/jats:italic>\n gene polymorphisms should be researched in the etiopathogenesis of SS.\n <\/jats:p>","DOI":"10.1155\/2014\/514891","type":"journal-article","created":{"date-parts":[[2014,4,10]],"date-time":"2014-04-10T17:03:03Z","timestamp":1397149383000},"page":"1-6","source":"Crossref","is-referenced-by-count":6,"title":["Etiopathogenesis of Sheehan\u2019s Syndrome: Roles of Coagulation Factors and TNF-Alpha"],"prefix":"10.1155","volume":"2014","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2519-5978","authenticated-orcid":true,"given":"Halit","family":"Diri","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Erciyes University Medical School, 38039 Kayseri, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5644-5442","authenticated-orcid":true,"given":"Elif Funda","family":"Sener","sequence":"additional","affiliation":[{"name":"Department of Medical Biology, Erciyes University Medical School, 38039 Kayseri, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fahri","family":"Bayram","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Erciyes University Medical School, 38039 Kayseri, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nazife","family":"Tascioglu","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, Erciyes University Medical School, 38039 Kayseri, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasin","family":"Simsek","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Erciyes University Medical School, 38039 Kayseri, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Munis","family":"Dundar","sequence":"additional","affiliation":[{"name":"Department of Medical 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