{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T13:32:02Z","timestamp":1778074322207,"version":"3.51.4"},"reference-count":30,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Federal Ministry of Education and Research","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Immunology Research"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>Heterogeneous nuclear ribonucleoproteins (hnRNPs) are potent autoantigenic targets in systemic autoimmune rheumatic diseases (SARD). Loss of tolerance to the RA33 complex consisting of hnRNP A2 and its alternatively spliced variants B1 and B2 has been the interest of rheumatologists. A novel ELISA for the detection of anti-hnRNP B1 autoantibodies has been developed to investigate the prevalence thereof in 397 patients with SARD, including patients with rheumatoid arthritis (RA), spondyloarthropathy (SPA), juvenile chronic arthritis, systemic lupus erythematosus (SLE), systemic sclerosis (SSc), and Sj\u00f6gren\u2019s syndrome (SS), in comparison to 174 controls. Anti-hnRNP B1 autoantibodies were significantly more prevalent in patients with SARD than controls (47\/397, 11.8% versus 2\/174, 1.1%;<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>). In particular, anti-hnRNP B1 were found more frequently in the disease cohorts than in the controls and were present in 24\/165 (14.5%) patients with RA, 6\/58 (10.3%) SPA, 11\/65 (16.9%) SSc, and 4\/50 (8.0%) SLE. In RA patients, anti-hnRNP B1 autoantibodies correlated significantly with C-reactive protein levels and erythrocyte sedimentation rate, while in patients with SSc it was associated with features of arterial wall stiffness and presence of hypertension. Anti-hnRNP B1 autoantibodies occur in SARD and seem to be correlated with distinct clinical characteristics in patients with RA and SSc.<\/jats:p>","DOI":"10.1155\/2014\/516593","type":"journal-article","created":{"date-parts":[[2014,5,4]],"date-time":"2014-05-04T17:06:48Z","timestamp":1399223208000},"page":"1-7","source":"Crossref","is-referenced-by-count":15,"title":["Anti-hnRNP B1 (RA33) Autoantibodies Are Associated with the Clinical Phenotype in Russian Patients with Rheumatoid Arthritis and Systemic Sclerosis"],"prefix":"10.1155","volume":"2014","author":[{"given":"Aleksey","family":"Maslyanskiy","sequence":"first","affiliation":[{"name":"Department of Rheumatology, Almazov Medical Research Centre, 197341 St. Petersburg, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalya","family":"Lazareva","sequence":"additional","affiliation":[{"name":"Laboratory of Autoimmune Diagnostics, St. Petersburg Pavlov State Medical University, 197022 St. Petersburg, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Polina","family":"Olinek","sequence":"additional","affiliation":[{"name":"Eichwald Department of Therapy and Rheumatology, Mechnikov Northwestern State University, 191015 St. Petersburg, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Schierack","sequence":"additional","affiliation":[{"name":"Faculty of Science, Brandenburg University of Technology Cottbus-Senftenberg, Gro\u00dfenhainer Stra\u00dfe 57, 01968 Senftenberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0579-202X","authenticated-orcid":true,"given":"Christian","family":"Hentschel","sequence":"additional","affiliation":[{"name":"R\/D, Medipan GmbH, Dahlewitz, 15827 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliane","family":"Cuccato","sequence":"additional","affiliation":[{"name":"R\/D, Medipan GmbH, Dahlewitz, 15827 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