{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T21:56:12Z","timestamp":1782251772631,"version":"3.54.5"},"reference-count":53,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p><jats:italic>Introduction<\/jats:italic>. Chemerin seems to be involved in pathogenesis of chronic hepatitis C (CHC). Hepatic expressions of chemerin and its receptor, chemokine receptor-like 1 (CMKLR1), in CHC have not been studied so far.<jats:italic>Aim<\/jats:italic>. To evaluate<jats:italic>chemerin<\/jats:italic>and<jats:italic>CMKLR1<\/jats:italic>hepatic expression together with serum<jats:italic>chemerin<\/jats:italic>concentration in CHC patients and to assess their relationship with metabolic and histopathological abnormalities.<jats:italic>Methods<\/jats:italic>. The study included 63 nonobese CHC patients. Transcription of<jats:italic>chemerin<\/jats:italic>and<jats:italic>CMKLR1<\/jats:italic>was assessed by quantitative real-time PCR, while serum chemerin was assessed by enzyme-linked immunosorbent assay.<jats:italic>Results<\/jats:italic>. Expression of<jats:italic>chemerin<\/jats:italic>and<jats:italic>CMKLR1<\/jats:italic>was present in the liver of all CHC patients regardless of sex or age. This expression was not associated with necroinflammatory activity and steatosis grade, fibrosis stage, and metabolic abnormalities. There was a negative association between serum chemerin and<jats:italic>chemerin<\/jats:italic>hepatic expression (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mi>r<\/mml:mi><\/mml:mrow><\/mml:math>= (\u22120.41),<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:mi>P<\/mml:mi><\/mml:mrow><\/mml:math>= 0.006).<jats:italic>Conclusion<\/jats:italic>. The study for the first time confirmed a marked expression of<jats:italic>chemerin<\/jats:italic>and<jats:italic>CMKLR1<\/jats:italic>in the liver of CHC patients. The study was performed using the homogenates of human liver tissue, so it is not possible to define whether hepatocytes or other cell types which are abundantly represented in the liver constitute the main source of<jats:italic>chemerin<\/jats:italic>and<jats:italic>CMKLR1<\/jats:italic>mRNA.<\/jats:p>","DOI":"10.1155\/2014\/517820","type":"journal-article","created":{"date-parts":[[2014,7,10]],"date-time":"2014-07-10T17:12:08Z","timestamp":1405012328000},"page":"1-12","source":"Crossref","is-referenced-by-count":14,"title":["Hepatic<i>Chemerin<\/i>and<i>Chemokine-Like Receptor 1<\/i>Expression in Patients with Chronic Hepatitis C"],"prefix":"10.1155","volume":"2014","author":[{"given":"Micha\u0142","family":"Kukla","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Medical University of Silesia, Ulica Medyk\u00f3w 14, 40-752 Katowice, 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