{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T20:28:51Z","timestamp":1740169731560,"version":"3.37.3"},"reference-count":21,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>The objective of this work was to study the coating process of nifedipine extended release pellets using Opadry and Opadry II, in a fluid bed coater with a Wurster insert. The coating process was studied using a complete experimental design of two factors at two levels for each polymer. The variables studied were the inlet air temperature and the coating suspension flow rate. The agglomerate fraction and coating efficiency were the analyzed response variables. The air temperature was the variable that most influenced the coating efficiency for both polymers. In addition, a study of the dissolution profiles of coated and uncoated pellets using 0.5% sodium lauryl sulfate in simulated gastric fluid without enzymes (pH 1.2) was conducted. The results showed a prolonged release profile for the coated and uncoated pellets that was very similar to the standards established by the U.S. Pharmacopoeia. The drug content and the release profiles were not significantly affected by storage at 40\u00b0C and 75% relative humidity. However, when exposed to direct sunlight and fluorescent light (light from fluorescent bulbs), the coated pellets lost only 5% of the drug content, while the uncoated ones lost more than 35%; furthermore, the dissolution profile of the uncoated pellets was faster.<\/jats:p>","DOI":"10.1155\/2014\/520758","type":"journal-article","created":{"date-parts":[[2014,3,18]],"date-time":"2014-03-18T17:02:01Z","timestamp":1395162121000},"page":"1-11","source":"Crossref","is-referenced-by-count":2,"title":["Film Coating of Nifedipine Extended Release Pellets in a Fluid Bed Coater with a Wurster Insert"],"prefix":"10.1155","volume":"2014","author":[{"given":"Luciane Franquelin Gomes","family":"de Souza","sequence":"first","affiliation":[{"name":"Mau\u00e1 Institute of Technology (IMT), Pra\u00e7a Mau\u00e1 1, 09580-900 S\u00e3o Caetano do Sul, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcello","family":"Nitz","sequence":"additional","affiliation":[{"name":"Mau\u00e1 Institute of Technology (IMT), Pra\u00e7a Mau\u00e1 1, 09580-900 S\u00e3o Caetano do Sul, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osvaldir Pereira","family":"Taranto","sequence":"additional","affiliation":[{"name":"School of Chemical Engineering, University of Campinas (UNICAMP), Avenue Albert Einstein 500, 13083-852 Campinas, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"12","first-page":"40","volume":"41","year":"1970","journal-title":"Manufacturing Chemist and Aerosol News"},{"key":"2","doi-asserted-by":"crossref","first-page":"53","DOI":"10.3109\/03639047809055639","volume":"4","year":"1978","journal-title":"Drug Development and Industrial Pharmacy"},{"key":"7","first-page":"33","volume":"56","year":"1985","journal-title":"Manufacturing Chemist"},{"key":"5","first-page":"29","volume":"60","year":"1989","journal-title":"Manufacturing Chemist"},{"key":"4","first-page":"38","volume":"106","year":"1970","journal-title":"Drug and Cosmetic Industry"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2009.07.013"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/j.powtec.2006.05.001"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/S0260-8774(01)00173-X"},{"key":"1","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.apt.2012.12.003","volume":"24","year":"2013","journal-title":"Advanced Powder Technology"},{"issue":"9-10","key":"11","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.3109\/03639048509057702","volume":"11","year":"1985","journal-title":"Drug Development and Industrial Pharmacy"},{"year":"2009","key":"19"},{"key":"20","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1111\/j.1365-2125.1987.tb03103.x","volume":"23","year":"1987","journal-title":"British Journal of Clinical Pharmacology"},{"issue":"4","key":"16","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1002\/j.1552-4604.1992.tb03843.x","volume":"32","year":"1992","journal-title":"Journal of Clinical Pharmacology"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-200407000-00011"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1080\/03639040600832827"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.3109\/03639045.2010.488644"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1081\/DDC-120005625"},{"key":"15","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1590\/S1516-93322004000400003","volume":"40","year":"2004","journal-title":"Revista Brasileira de Ci\u00eancias Farmac\u00eauticas"},{"year":"2005","key":"3"},{"year":"2009","key":"14"},{"first-page":"96","volume-title":"Coating and agglomeration in fluidized beds","year":"2013","key":"13"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2014\/520758.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2014\/520758.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2014\/520758.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,22]],"date-time":"2017-06-22T05:50:34Z","timestamp":1498110634000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/bmri\/2014\/520758\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":21,"alternative-id":["520758","520758"],"URL":"https:\/\/doi.org\/10.1155\/2014\/520758","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"type":"print","value":"2314-6133"},{"type":"electronic","value":"2314-6141"}],"subject":[],"published":{"date-parts":[[2014]]}}}