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Previous work revealed that this mutant has a shortened body axis and eye defects including a defective hyaloid vasculature, focal corneal dysplasia, and loss of the crystalline lens. While these studies highlight the importance of laminin<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mi>\u03b1<\/mml:mi><\/mml:mrow><\/mml:math>1 in lens development, a detailed analysis of the lens defects seen in these mutants was not reported. In the present study, we analyze the lenticular anomalies seen in the<jats:italic>lama1<\/jats:italic><jats:sup><jats:italic>a69\/a69<\/jats:italic><\/jats:sup>mutants and show that the lens defects result from the anterior extrusion of lens material from the eye secondary to structural defects in the lens capsule and developing corneal epithelium associated with basement membrane loss. Our analysis provides further insights into the role of the lens capsule and corneal basement membrane in the structural integrity of the developing eye.<\/jats:p>","DOI":"10.1155\/2014\/524929","type":"journal-article","created":{"date-parts":[[2014,1,15]],"date-time":"2014-01-15T21:02:19Z","timestamp":1389819739000},"page":"1-9","source":"Crossref","is-referenced-by-count":15,"title":["Lens Extrusion from<i>Laminin Alpha 1<\/i>Mutant Zebrafish"],"prefix":"10.1155","volume":"2014","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2729-9351","authenticated-orcid":true,"given":"Mallika","family":"Pathania","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, University of Delaware, 327 Wolf Hall Newark, DE 19716, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena V.","family":"Semina","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226, 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