{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:49:54Z","timestamp":1787017794857,"version":"build-2736575974"},"reference-count":29,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>\n                    <jats:italic>Objectives.<\/jats:italic>\n                    To report the decline of renal function after radical nephroureterectomy (RNU) in upper tract urothelial carcinoma (UTUC) patients and to develop a nomogram to predict ineligibility for cisplatin-based adjuvant chemotherapy (AC).\n                    <jats:italic>Methods.<\/jats:italic>\n                    We retrospectively analyzed 606 consecutive Chinese UTUC patients treated by RNU from 2000 to 2010. We chose an eGFR of 60 and 45\u2009ml\/min\/1.73\u2009m\n                    <jats:sup>2<\/jats:sup>\n                    as cut-offs for full-dose and reduced-dose AC eligibility.\n                    <jats:italic>Results.<\/jats:italic>\n                    Median eGFR for all patients before and after surgery was 64 and 49\u2009ml\/min\/1.73\u2009m\n                    <jats:sup>2<\/jats:sup>\n                    (\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                      <mml:mi>P<\/mml:mi>\n                      <mml:mo>&lt;<\/mml:mo>\n                      <mml:mn>0.001<\/mml:mn>\n                    <\/mml:math>\n                    ). The proportion of patients ineligible to receive full-dose and reduced-dose AC changed from 42% to 74% and from 20% to 38.1%. Older age (OR = 1.007), preoperative eGFR (OR = 0.993), absence of hydronephrosis (OR = 0.801), smaller tumor size (OR = 0.962), and tumor without multifocality (OR = 0.876) were predictive for ineligibility for full-dose AC. Preoperative eGFR (OR = 0.991), absence of hydronephrosis (OR = 0.881), tumor located in renal pelvis (OR = 1.164), and smaller tumor size (OR = 0.969) could predict ineligibility for reduced-dose AC. The c-index of the two models was 0.757 and 0.836. Postoperative renal function was not associated with worse survival.\n                    <jats:italic>Conclusions.<\/jats:italic>\n                    Older age, lower preoperative eGFR, smaller tumor size, tumor located in renal pelvis, and absence of hydronephrosis or multifocality were predictors of postoperative renal insufficiency.\n                  <\/jats:p>","DOI":"10.1155\/2014\/529186","type":"journal-article","created":{"date-parts":[[2014,8,10]],"date-time":"2014-08-10T17:06:12Z","timestamp":1407690372000},"page":"1-10","source":"Crossref","is-referenced-by-count":20,"title":["Nomogram Predicting Renal Insufficiency after Nephroureterectomy for Upper Tract Urothelial Carcinoma in the Chinese Population: Exclusion of Ineligible Candidates for Adjuvant Chemotherapy"],"prefix":"10.1155","volume":"2014","author":[{"given":"Dong","family":"Fang","sequence":"first","affiliation":[{"name":"Department of Urology, Peking University First Hospital, Institute of Urology, Peking University, National Urological Cancer Centre, No. 8 Xishiku Street, Xicheng District, Beijing 100034, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qifu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Urology, Jilin Tumour Hospital, No. 1018 Huguang Road, Chaoyang District, Changchun, Jilin 130021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7030-0856","authenticated-orcid":true,"given":"Xuesong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Urology, Peking University First Hospital, Institute of Urology, Peking University, National Urological Cancer Centre, No. 8 Xishiku Street, Xicheng District, Beijing 100034, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Urology, Peking University First Hospital, Institute of Urology, Peking University, National Urological Cancer Centre, No. 8 Xishiku Street, Xicheng District, Beijing 100034, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gengyan","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Urology, Peking University First Hospital, Institute of Urology, Peking University, National Urological Cancer Centre, No. 8 Xishiku Street, Xicheng District, Beijing 100034, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Urology, Peking University First Hospital, Institute of Urology, Peking University, National Urological Cancer Centre, No. 8 Xishiku Street, Xicheng District, Beijing 100034, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaopeng","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Urology, Peking University First Hospital, Institute of Urology, Peking University, National Urological Cancer Centre, No. 8 Xishiku Street, Xicheng District, Beijing 100034, China"},{"name":"Department of Urology, Tangdu Hospital, Fourth Military Medical University, No.1 Xinsi Road, Baqiao District, Xi\u2019an, Shaanxi 710038, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Urology, Peking University First Hospital, Institute of Urology, Peking University, National Urological Cancer Centre, No. 8 Xishiku Street, Xicheng District, Beijing 100034, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Urology, Peking University First Hospital, Institute of Urology, Peking University, National Urological Cancer Centre, No. 8 Xishiku Street, Xicheng District, Beijing 100034, 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