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Herein, we report two cases of recurrent oral plasmacytoma progressed to MM, in which the first clinical sign of a more widespread disease was limited to the mouth. Based on our experience, we recommend a strict workup for the differential diagnosis between EMP, SBP, and MM for patients with oral plasmacytoma, including radiological exam of the skeleton, magnetic resonance imaging (MRI) of the bone, and positive emission tomography (FDG-PET). MRI and possibly PET can all be used to more sensitively detect EM plasmacytoma sites.<\/jats:p>","DOI":"10.1155\/2014\/529452","type":"journal-article","created":{"date-parts":[[2014,11,25]],"date-time":"2014-11-25T21:01:05Z","timestamp":1416949265000},"page":"1-7","source":"Crossref","is-referenced-by-count":3,"title":["Oral Lesion as Unusual First Manifestation of Multiple Myeloma: Case Reports and Review of the Literature"],"prefix":"10.1155","volume":"2014","author":[{"given":"A.","family":"Romano","sequence":"first","affiliation":[{"name":"Department of Clinical and Molecular Biomedicine, Section of Haematology, University of Catania, Via Citelli 6, 95124 Catania, Italy"},{"name":"Ospedale Ferrarotto, Divisione di Ematologia, Via Citelli 6, 95124 Catania, Italy"},{"name":"Scuola Superiore di Catania, Via San Nullo 5 I, 95125 Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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