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The aim of this study was to determine the therapeutic efficacy of<jats:italic>\u03b4<\/jats:italic>-tocotrienol, in the rat model of collagen-induced arthritis (CIA). Arthritis was induced by intradermal injection of collagen type II emulsified in complete Freund\u2019s adjuvant. CIA rats were orally treated with<jats:italic>\u03b4<\/jats:italic>-tocotrienol (10\u2009mg\/kg) or glucosamine hydrochloride (300\u2009mg\/kg) from day 25 to 50. Efficacy was assessed based on the ability to reduce paw edema, histopathological changes, suppression of collagen-specific T-cells, and a reduction in C-reactive protein (CRP) levels. It was established that<jats:italic>\u03b4<\/jats:italic>-tocotrienol had the most significant impact in lowering paw edema when compared to glucosamine treatment. Paw edema changes correlated well with histopathological analysis where there was a significant reversal of changes in groups treated with<jats:italic>\u03b4<\/jats:italic>-tocotrienol. The results suggest that<jats:italic>\u03b4<\/jats:italic>-tocotrienol is efficient in amelioration of collagen-induced arthritis. Vitamin E delta-tocotrienol may be of therapeutic value against rheumatoid arthritis.<\/jats:p>","DOI":"10.1155\/2014\/539540","type":"journal-article","created":{"date-parts":[[2014,7,10]],"date-time":"2014-07-10T21:12:14Z","timestamp":1405026734000},"page":"1-8","source":"Crossref","is-referenced-by-count":21,"title":["Therapeutic Efficacy of Vitamin E<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mi mathvariant=\"bold-italic\">\u03b4<\/mml:mi><\/mml:mrow><\/mml:math>-Tocotrienol in Collagen-Induced Rat Model of Arthritis"],"prefix":"10.1155","volume":"2014","author":[{"given":"Nagaraja","family":"Haleagrahara","sequence":"first","affiliation":[{"name":"Discipline of Physiology and Pharmacology, School of Veterinary and Biomedical Sciences, Faculty of Medicine, Health and Molecular Sciences, James Cook University, Townsville QLD 4811, 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