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In diabetic group, blood glucose levels significantly increased while insulinemia level markedly decreased. At the end of treatment, VOSO<jats:sub>4<\/jats:sub>at a dose of 10\u2009mg\/Kg normalized blood glucose level in diabetic group, restored insulinemia, and significantly improved insulin sensitivity. VOSO<jats:sub>4<\/jats:sub>also increased in a dose-dependent manner the number of insulin immunopositive beta cells in pancreatic islets of nondiabetic rats. Furthermore, in the STZ-diabetic group, the decrease in the number of insulin immunopositive beta cells was corrected to reach the control level mainly with the higher dose of vanadium. Therefore, VOSO<jats:sub>4<\/jats:sub>treatment normalized plasma glucose and insulin levels and improved insulin sensitivity in STZ-experimental diabetes and induced beta cells proliferation and\/or regeneration in normal or diabetic rats.<\/jats:p>","DOI":"10.1155\/2014\/540242","type":"journal-article","created":{"date-parts":[[2014,8,19]],"date-time":"2014-08-19T21:14:51Z","timestamp":1408482891000},"page":"1-7","source":"Crossref","is-referenced-by-count":21,"title":["Vanadyl Sulfate Treatment Stimulates Proliferation and Regeneration of Beta Cells in Pancreatic Islets"],"prefix":"10.1155","volume":"2014","author":[{"given":"Samira","family":"Missaoui","sequence":"first","affiliation":[{"name":"Laboratory of Integrated Physiology, Faculty of Sciences of Bizerte, University of Carthage, 7021 Jarzouna, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kh\u00e9mais","family":"Ben Rhouma","sequence":"additional","affiliation":[{"name":"Laboratory of Integrated 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