{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T18:26:54Z","timestamp":1771266414894,"version":"3.50.1"},"reference-count":38,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2014,11,16]],"date-time":"2014-11-16T00:00:00Z","timestamp":1416096000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Scholarly Research Notices"],"published-print":{"date-parts":[[2014,11,16]]},"abstract":"<jats:p>Developing a single analytical method for estimation of individual drug from a multidrug composition is a very challenging task. A complexation, derivatization, extraction, evaporation, and sensitive-free direct UV spectrophotometric method is developed and validated for the simultaneous estimation of some antiviral drugs such as emtricitabine (EMT), tenofovir disoproxil fumarate (TDF), and rilpivirine HCl (RPV) in tablet dosage form by Vierordt\u2019s method. The solutions of standard and sample were prepared in methanol. The <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:msub><mml:mrow><mml:mi>\u03bb<\/mml:mi><\/mml:mrow><mml:mrow><mml:mi>max<\/mml:mi><mml:mo>\u2061<\/mml:mo><\/mml:mrow><\/mml:msub><\/mml:mrow><\/mml:math> for emtricitabine, tenofovir disoproxil fumarate, and rilpivirine hydrochloride were 240.8\u2009nm, 257.6\u2009nm, and 305.6\u2009nm, respectively. Calibration curves are linear in the concentration ranges 4\u201312\u2009<jats:italic>\u03bc<\/jats:italic>g\/ml for EMT, 6\u201318\u2009<jats:italic>\u03bc<\/jats:italic>g\/ml for TDF, and 0.5\u20131.5\u2009<jats:italic>\u03bc<\/jats:italic>g\/ml for RPV, respectively. Results of analysis of simultaneous equation method were analyzed and validated for various parameters according to ICH guidelines.<\/jats:p>","DOI":"10.1155\/2014\/541727","type":"journal-article","created":{"date-parts":[[2014,11,16]],"date-time":"2014-11-16T21:03:19Z","timestamp":1416171799000},"page":"1-8","source":"Crossref","is-referenced-by-count":11,"title":["Simultaneous Spectrophotometric Method for Determination of Emtricitabine and Tenofovir Disoproxil Fumarate in Three-Component Tablet Formulation Containing Rilpivirine Hydrochloride"],"prefix":"10.1155","volume":"2014","author":[{"given":"S.","family":"Venkatesan","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Annamalai University, Tamil Nadu 608002, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Kannappan","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Annamalai University, Tamil Nadu 608002, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","reference":[{"key":"33","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2004.09.041"},{"key":"30","year":"1990"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1177\/10529002013003007"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-2918(02)80058-3"},{"issue":"1","key":"21","first-page":"150","volume":"4","year":"2013","journal-title":"International Research Journal of Pharmacy"},{"issue":"8","key":"27","first-page":"4600","volume":"5","year":"2012","journal-title":"Journal of Pharmacy Research"},{"issue":"3","key":"2","first-page":"1085","volume":"6","year":"2011","journal-title":"Digest Journal of Nanomaterials and Biostructures"},{"issue":"1","key":"4","first-page":"27","volume":"22","year":"2009","journal-title":"Pakistan Journal of Pharmaceutical Sciences"},{"issue":"2","key":"28","doi-asserted-by":"crossref","first-page":"29","DOI":"10.9790\/5736-0122933","volume":"1","year":"2012","journal-title":"IOSR Journal of Applied Chemistry"},{"issue":"1","key":"36","first-page":"9","volume":"1","year":"2012","journal-title":"Research & Review: Journal of Pharmaceutical Analysis"},{"issue":"1","key":"24","first-page":"199","volume":"3","year":"2011","journal-title":"International Journal of Drug Development and Research"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/j.arabjc.2013.06.024"},{"issue":"1","key":"25","first-page":"28","volume":"1","year":"2009","journal-title":"International Journal of Pharmaceutical and Clinical Research"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1080\/00032710801910742"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2007.04.015"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/S1570-0232(02)00933-9"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1016\/S1570-0232(03)00225-3"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.4103\/0250-474X.51951"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2005.10.015"},{"issue":"1","key":"23","first-page":"23","volume":"3","year":"2011","journal-title":"International Journal of ChemTech Research"},{"issue":"3","key":"1","first-page":"1874","volume":"3","year":"2011","journal-title":"International Journal of PharmTech Research"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2005.06.019"},{"issue":"10","key":"9","first-page":"2769","volume":"30","year":"2007","journal-title":"Journal of Liquid Chromatography and Related Technologies"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.200800688"},{"issue":"4","key":"32","first-page":"522","volume":"1","year":"2008","journal-title":"Research Journal of Pharmacy and Technology"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/878295"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.4103\/2229-4708.103876"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2008.07.022"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.200600429"},{"issue":"1","key":"13","first-page":"450","volume":"3","year":"2013","journal-title":"American Journal of PharmTech Research"},{"issue":"3","key":"11","first-page":"240","volume":"6","year":"2013","journal-title":"Research Journal of Pharmacy and Technology"},{"issue":"4","key":"38","first-page":"1183","volume":"1","year":"2012","journal-title":"World Journal of Pharmaceutical Research"},{"key":"16","year":"2005"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.arabjc.2013.07.013"},{"key":"17","year":"1989"},{"key":"6","year":"1997"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.4103\/0250-474X.73926"},{"issue":"3","key":"22","first-page":"1586","volume":"2","year":"2010","journal-title":"International Journal of ChemTech Research"}],"container-title":["International Scholarly Research Notices"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/archive\/2014\/541727.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/archive\/2014\/541727.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/archive\/2014\/541727.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,9]],"date-time":"2020-12-09T17:44:00Z","timestamp":1607535840000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/isrn\/2014\/541727\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11,16]]},"references-count":38,"alternative-id":["541727","541727"],"URL":"https:\/\/doi.org\/10.1155\/2014\/541727","relation":{},"ISSN":["2356-7872"],"issn-type":[{"value":"2356-7872","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11,16]]}}}