{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T21:43:33Z","timestamp":1768340613455,"version":"3.49.0"},"reference-count":59,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"German Federal Ministry of Education and Research","award":["01GV0610"],"award-info":[{"award-number":["01GV0610"]}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["01GV0610"],"award-info":[{"award-number":["01GV0610"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Open Access Publishing Fund of Tuebingen University","award":["01GV0610"],"award-info":[{"award-number":["01GV0610"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p><jats:italic>Objectives<\/jats:italic>. Neurobiologically, panic disorder (PD) is supposed to be characterised by cerebral hypofrontality. Via functional near-infrared spectroscopy (fNIRS), we investigated whether prefrontal hypoactivity during cognitive tasks in PD-patients compared to healthy controls (HC) could be replicated. As intermittent theta burst stimulation (iTBS) modulates cortical activity, we furthermore investigated its ability to normalise prefrontal activation.<jats:italic>Methods<\/jats:italic>. Forty-four PD-patients, randomised to sham or verum group, received 15 iTBS-sessions above the left dorsolateral prefrontal cortex (DLPFC) in addition to psychoeducation. Before first and after last iTBS-treatment, cortical activity during a verbal fluency task was assessed via fNIRS and compared to the results of 23 HC.<jats:italic>Results<\/jats:italic>. At baseline, PD-patients showed hypofrontality including the DLPFC, which differed significantly from activation patterns of HC. However, verum iTBS did not augment prefrontal fNIRS activation. Solely after sham iTBS, a significant increase of measured fNIRS activation in the left inferior frontal gyrus (IFG) during the phonological task was found.<jats:italic>Conclusion<\/jats:italic>. Our results support findings that PD is characterised by prefrontal hypoactivation during cognitive performance. However, verum iTBS as an \u201cadd-on\u201d to psychoeducation did not augment prefrontal activity. Instead we only found increased fNIRS activation in the left IFG after sham iTBS application. Possible reasons including task-related psychophysiological arousal are discussed.<\/jats:p>","DOI":"10.1155\/2014\/542526","type":"journal-article","created":{"date-parts":[[2014,3,18]],"date-time":"2014-03-18T17:02:05Z","timestamp":1395162125000},"page":"1-12","source":"Crossref","is-referenced-by-count":31,"title":["Does rTMS Alter Neurocognitive Functioning in Patients with Panic Disorder\/Agoraphobia? An fNIRS-Based Investigation of Prefrontal Activation during a Cognitive Task and Its Modulation via Sham-Controlled rTMS"],"prefix":"10.1155","volume":"2014","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0416-4534","authenticated-orcid":true,"given":"Saskia","family":"Deppermann","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, University of Tuebingen, Calwerstr 14, 72076 Tuebingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9843-4936","authenticated-orcid":true,"given":"Nadja","family":"Vennewald","sequence":"additional","affiliation":[{"name":"Mood and Anxiety Disorders Research Unit, Department of Psychiatry and Psychotherapy, University of Muenster, Albert-Schweitzer-Campus 1, Building A9, 48149 Muenster, 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