{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T23:32:19Z","timestamp":1787614339585,"version":"build-2736575974"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,12,25]],"date-time":"2014-12-25T00:00:00Z","timestamp":1419465600000},"content-version":"vor","delay-in-days":358,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Administration of Traditional Chinese Medicine of Guangdong Province, China","award":["2010105"],"award-info":[{"award-number":["2010105"]}]},{"name":"Administration of Traditional Chinese Medicine of Guangdong Province, China","award":["81100728"],"award-info":[{"award-number":["81100728"]}]},{"name":"Administration of Traditional Chinese Medicine of Guangdong Province, China","award":["2012B050600017"],"award-info":[{"award-number":["2012B050600017"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2010105"],"award-info":[{"award-number":["2010105"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81100728"],"award-info":[{"award-number":["81100728"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2012B050600017"],"award-info":[{"award-number":["2012B050600017"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Cooperation Projects of Science and Technology Program of Guangdong Province","award":["2010105"],"award-info":[{"award-number":["2010105"]}]},{"name":"Cooperation Projects of Science and Technology Program of Guangdong Province","award":["81100728"],"award-info":[{"award-number":["81100728"]}]},{"name":"Cooperation Projects of Science and Technology Program of Guangdong Province","award":["2012B050600017"],"award-info":[{"award-number":["2012B050600017"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:p>Periodontitis is an inflammatory disease that causes osteolysis and tooth loss. It is known that the nuclear factor kappa B (NF\u2010<jats:italic>\u03ba<\/jats:italic>B) signalling pathway plays a key role in the progression of inflammation and osteoclastogenesis in periodontitis. Parthenolide (PTL), a sesquiterpene lactone extracted from the shoots of <jats:italic>Tanacetum parthenium<\/jats:italic>, has been shown to possess anti\u2010inflammatory properties in various diseases. In the study reported herein, we investigated the effects of PTL on the inflammatory and osteoclastogenic response of human periodontal ligament\u2010derived cells (hPDLCs) and revealed the signalling pathways in this process. Our results showed that PTL decreased NF\u2010<jats:italic>\u03ba<\/jats:italic>B activation, I\u2010<jats:italic>\u03ba<\/jats:italic>B degradation, and ERK activation in hPDLCs. PTL significantly reduced the expression of inflammatory (IL\u20101<jats:italic>\u03b2<\/jats:italic>, IL\u20106, and TNF\u2010<jats:italic>\u03b1<\/jats:italic>) and osteoclastogenic (RANKL, OPG, and M\u2010CSF) genes in LPS\u2010stimulated hPDLCs. In addition, PTL attenuated hPDLC\u2010induced osteoclastogenic differentiation of macrophages (RAW264.7 cells), as well as reducing gene expression of osteoclast\u2010related markers in RAW264.7 cells in an hPDLC\u2010macrophage coculture model. Taken together, these results demonstrate the anti\u2010inflammatory and antiosteoclastogenic activities of PTL in hPDLCs <jats:italic>in vitro<\/jats:italic>. These data offer fundamental evidence supporting the potential use of PTL in periodontitis treatment.<\/jats:p>","DOI":"10.1155\/2014\/546097","type":"journal-article","created":{"date-parts":[[2014,12,25]],"date-time":"2014-12-25T21:02:22Z","timestamp":1419541342000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Anti\u2010Inflammatory and Antiosteoclastogenic Activities of Parthenolide on Human Periodontal Ligament Cells <i>In Vitro<\/i>"],"prefix":"10.1155","volume":"2014","author":[{"given":"Xufang","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6837-4832","authenticated-orcid":false,"given":"Chen","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1785-3491","authenticated-orcid":false,"given":"Yin","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueli","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,12,25]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2337"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/0022034509340008"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2009.01265.x"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1080\/07853890600800103"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2004.04.023"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2011.01374.x"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-011-9346-0"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1124\/mol.61.5.953"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9440(10)64425-2"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1359\/JBMR.040919"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.163.10.5617"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-010-0456-0"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biophys-083012-130338"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.70.6.3143-3148.2002"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00348.2011"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2004.09.011"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1186\/1476-9255-8-26"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2013.415"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.20948"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051x.2001.028003233.x"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.160.1.403"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1996.1433"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0278-6915(03)00146-7"},{"key":"e_1_2_8_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2011.09.022"},{"key":"e_1_2_8_25_2","doi-asserted-by":"publisher","DOI":"10.1186\/1476-9255-2-6"},{"key":"e_1_2_8_26_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2003.74.3.391"},{"key":"e_1_2_8_27_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2006.050338"},{"key":"e_1_2_8_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/s001090100226"},{"key":"e_1_2_8_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4401285"},{"key":"e_1_2_8_30_2","doi-asserted-by":"publisher","DOI":"10.1007\/s007740170024"},{"key":"e_1_2_8_31_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.289.5484.1504"}],"container-title":["Evidence-Based Complementary and Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2014\/546097.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2014\/546097.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2014\/546097","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T16:54:40Z","timestamp":1723049680000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2014\/546097"}},"subtitle":[],"editor":[{"given":"Adair","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,1]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["10.1155\/2014\/546097"],"URL":"https:\/\/doi.org\/10.1155\/2014\/546097","archive":["Portico"],"relation":{},"ISSN":["1741-427X","1741-4288"],"issn-type":[{"value":"1741-427X","type":"print"},{"value":"1741-4288","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1]]},"assertion":[{"value":"2014-10-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-12-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-12-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"546097"}}