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For this reason there has been a constant search for drugs and natural products able to prevent or at least to mitigate these problems. In the present study the effects of an aqueous extract of\n                    <jats:italic>Agaricus blazei<\/jats:italic>\n                    , a medicinal mushroom, on the oxidative state and on the functionality of mitochondria from the brain of old rats (21 months) were conducted. The extract was administered intragastrically during 21 days at doses of 200\u2009mg\/kg. The administration of the\n                    <jats:italic>A. blazei<\/jats:italic>\n                    extract was protective to the brain of old rats against oxidative stress by decreasing the lipid peroxidation levels and the reactive oxygen species content and by increasing the nonenzymic and enzymic antioxidant capacities. Administration of the\n                    <jats:italic>A. blazei<\/jats:italic>\n                    extract also increased the activity of several mitochondrial respiratory enzymes and, depending on the substrate, the mitochondrial coupled respiration.\n                  <\/jats:p>","DOI":"10.1155\/2014\/563179","type":"journal-article","created":{"date-parts":[[2014,4,28]],"date-time":"2014-04-28T17:04:42Z","timestamp":1398704682000},"page":"1-13","source":"Crossref","is-referenced-by-count":15,"title":["Effects of Treating Old Rats with an Aqueous\n                    <i>Agaricus blazei<\/i>\n                    Extract on Oxidative and Functional Parameters of the Brain Tissue and Brain Mitochondria"],"prefix":"10.1155","volume":"2014","author":[{"given":"Anacharis B.","family":"de S\u00e1-Nakanishi","sequence":"first","affiliation":[{"name":"Department of Biochemistry, University of Maring\u00e1, Avenida Colombo 5790, 87020900 Maring\u00e1, PR, 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