{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T13:18:03Z","timestamp":1761743883121,"version":"3.37.3"},"reference-count":23,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,19]],"date-time":"2014-01-19T00:00:00Z","timestamp":1390089600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005285","name":"Funda\u00e7\u00e3o de Apoio \u00e0 Pesquisa do Estado de Goi\u00e1s","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005285","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ISRN Inflammation"],"published-print":{"date-parts":[[2014,1,19]]},"abstract":"<jats:p>Snake venom has been the subject of numerous studies in an attempt to find properties and biological effects that may be beneficial to man. In this study we evaluated<jats:italic>in vitro<\/jats:italic>the effects of<jats:italic>Crotalus durissus terrificus<\/jats:italic>(Cdt) and<jats:italic>Crotalus durissus collilineatus<\/jats:italic>(Cdc) venom in human peripheral blood mononuclear cells (PBMCs). At 24\u2009h, a significant decrease of viable cells was observed in cells stimulated with the Cdc venom at 0.0005\u2009mg\/mL and 0.005\u2009mg\/mL compared to the negative control. At 48\u2009h, a significant decrease of viable cells was observed only in cells stimulated with Cdc venom at 0.005\u2009mg\/mL. A significant increase of TNF-<jats:italic>\u03b1<\/jats:italic>and IL-10 was detected 48 hours after culture of PBMC with Cdc, but not with Cdt venom. The expression of CD69 and PD1 (programmed death-1), activation and regulatory cell markers, on CD8+ and CD8\u2212 T cells did not change in the presence of Cdt and Cdc venom. Our results suggest the presence of proinflammatory and anti-inflammatory components in the Cdc venom. Further analysis should be done to identify those Cdc venom components as it has been done for the Cdt venom by other authors, indicating that modulatory components are found in the venom of different species of<jats:italic>Crotalus<\/jats:italic>snakes.<\/jats:p>","DOI":"10.1155\/2014\/563628","type":"journal-article","created":{"date-parts":[[2014,1,20]],"date-time":"2014-01-20T06:20:24Z","timestamp":1390198824000},"page":"1-7","source":"Crossref","is-referenced-by-count":6,"title":["<i>Crotalus durissus collilineatus<\/i>Venom Induces TNF-<b><i>\u03b1<\/i><\/b>and IL-10 Production in Human Peripheral Blood Mononuclear Cells"],"prefix":"10.1155","volume":"2014","author":[{"given":"Camila Bastos","family":"Ribeiro","sequence":"first","affiliation":[{"name":"Departamento de Biomedicina e Farm\u00e1cia, Pontif\u00edcia Universidade Cat\u00f3lica de Goi\u00e1s, 74605-140 Goiania, GO, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00e9ssica Cristina dos","family":"Santos","sequence":"additional","affiliation":[{"name":"Departamento de Biomedicina e Farm\u00e1cia, Pontif\u00edcia Universidade Cat\u00f3lica de Goi\u00e1s, 74605-140 Goiania, GO, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacyelle Medeiros","family":"Silva","sequence":"additional","affiliation":[{"name":"Departamento de Biomedicina e Farm\u00e1cia, Pontif\u00edcia Universidade Cat\u00f3lica de Goi\u00e1s, 74605-140 Goiania, GO, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro Henrique Silva de","family":"Godoi","sequence":"additional","affiliation":[{"name":"Departamento de Biomedicina e Farm\u00e1cia, Pontif\u00edcia Universidade Cat\u00f3lica de Goi\u00e1s, 74605-140 Goiania, GO, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta Regina","family":"Magalh\u00e3es","sequence":"additional","affiliation":[{"name":"Centro de Estudos e Pesquisas Biol\u00f3gicas (CEPB), Pontif\u00edcia Universidade Cat\u00f3lica de Goi\u00e1s, 74605-010 Goiania, GO, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00f4nica","family":"Spadafora-Ferreira","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Imunogen\u00e9tica, Instituto Butantan, 05503-900 S\u00e3o Paulo, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone Gon\u00e7alves","family":"Fonseca","sequence":"additional","affiliation":[{"name":"Instituto de Patologia Tropical e Sa\u00fade P\u00fablica, Universidade Federal de Goi\u00e1s, 74605-050 Goiania, GO, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irmtraut Araci Hoffman","family":"Pfrimer","sequence":"additional","affiliation":[{"name":"Departamento de Biomedicina e Farm\u00e1cia, Pontif\u00edcia Universidade Cat\u00f3lica de Goi\u00e1s, 74605-140 Goiania, GO, 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