{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T20:29:12Z","timestamp":1740169752390,"version":"3.37.3"},"reference-count":29,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p><jats:italic>Introduction<\/jats:italic>. Our aim was to analyze our clinical experience with dabigatran etexilate in secondary stroke prevention.<jats:italic>Methods<\/jats:italic>. We retrospectively included patients starting dabigatran etexilate for secondary stroke prevention from March 2010 to December 2012. Efficacy and safety variables were registered.<jats:italic>Results<\/jats:italic>. 106 patients were included, median follow-up of 12 months (range 1\u201331). Fifty-six females (52.8%), mean age 76.4 (range 50\u201395, SD 9.8), median CHADS2 4 (range 2\u20136), CHA2DS2-VASc 5 (range 2\u20139), and HAS-BLED 2 (range 1\u20135). Indication for dabigatran etexilate was ischemic stroke in 101 patients and acute cerebral hemorrhage (CH) due to warfarin in 5 (4.7%). Dabigatran etexilate 110\u2009mg bid was prescribed in 71 cases (67%) and 150\u2009mg bid was prescribed in the remaining. Seventeen patients (16%) suffered 20 complications during follow-up. Ischemic complications (10) were 6 transient ischemic attacks (TIA), 3 ischemic strokes, and 1 acute coronary syndrome. Hemorrhagic complications (10) were CH (1), gastrointestinal bleeding (6), mild hematuria (2), and mild metrorrhagia (1), leading to dabigatran etexilate discontinuation in 3 patients. Patients with previous CH remained uneventful. Three patients died (pneumonia, congestive heart failure, and acute cholecystitis) and 9 were lost during follow-up.<jats:italic>Conclusions<\/jats:italic>. Dabigatran etexilate was safe and effective in secondary stroke prevention in clinical practice, including a small number of patients with previous history of CH.<\/jats:p>","DOI":"10.1155\/2014\/567026","type":"journal-article","created":{"date-parts":[[2014,7,15]],"date-time":"2014-07-15T17:06:40Z","timestamp":1405444000000},"page":"1-6","source":"Crossref","is-referenced-by-count":3,"title":["Dabigatran in Secondary Stroke Prevention: Clinical Experience with 106 Patients"],"prefix":"10.1155","volume":"2014","author":[{"given":"Alicia","family":"DeFelipe-Mimbrera","sequence":"first","affiliation":[{"name":"Stroke Unit, Neurology Department, IRYCIS, University Hospital Ram\u00f3n y Cajal, Carretera de Colmenar Viejo km 9,100, 28034 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Araceli Alonso","family":"C\u00e1novas","sequence":"additional","affiliation":[{"name":"Stroke Unit, Neurology Department, IRYCIS, University Hospital Ram\u00f3n y Cajal, 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