{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:16:41Z","timestamp":1770077801255,"version":"3.49.0"},"reference-count":19,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,30]],"date-time":"2014-01-30T00:00:00Z","timestamp":1391040000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI12\/01280"],"award-info":[{"award-number":["PI12\/01280"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ISRN Dermatology"],"published-print":{"date-parts":[[2014,1,30]]},"abstract":"<jats:p>With the aim of clarifying the role of several polymorphisms around the<jats:italic>HLA-C<\/jats:italic>locus in the clinical expression of PsA, the distribution of several polymorphic markers and genes located around the<jats:italic>HLA-C<\/jats:italic>locus was analyzed in a well-established cohort of 110 patients with PsA, 50 patients with psoriasis alone, and 110 healthy controls. The frequency of these genes was also analyzed by PsA articular models, based on three main subgroups: oligoarthritis, polyarthritis, and spondylitis. Distal interphalangeal joint (DIP) involvement was associated with the presence of<jats:italic>MICB-CA20<\/jats:italic>(OR 6.0, 95% CI: 1.58\u201322.69,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.005<\/mml:mn><\/mml:math>).<jats:italic>HLA-DRB<\/jats:italic><mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:mrow><mml:mi>*<\/mml:mi><\/mml:mrow><\/mml:mrow><\/mml:math><jats:italic>07<\/jats:italic>was associated with oligoarticular forms of PsA (OR 4.1, 95% CI: 1.8\u20139.3,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.00<\/mml:mn><mml:mn>07<\/mml:mn><\/mml:math>). The spondylitic forms overexpressed the antigen<jats:italic>HLA-B<\/jats:italic><mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mrow><mml:mrow><mml:mi>*<\/mml:mi><\/mml:mrow><\/mml:mrow><\/mml:math><jats:italic>27<\/jats:italic>(OR 5.7, 95% CI: 2.4\u201313.6,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.00<\/mml:mn><mml:mn>01<\/mml:mn><\/mml:math>).<jats:italic>MICA-A5.1<\/jats:italic>showed association with polyarthritis (OR 3.7, 95% CI: 1.5\u20138.8,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.00<\/mml:mn><mml:mn>6<\/mml:mn><\/mml:math>). Genes telomeric to<jats:italic>HLA-C<\/jats:italic>were overexpressed in psoriasis but not in PsA subphenotypes. This study shows that the region centromeric to<jats:italic>HLA-C<\/jats:italic>is a key region that expresses not only disease risk genes but also genes that help explain the phenotypic variability of PsA.<\/jats:p>","DOI":"10.1155\/2014\/570178","type":"journal-article","created":{"date-parts":[[2014,1,30]],"date-time":"2014-01-30T21:16:45Z","timestamp":1391116605000},"page":"1-5","source":"Crossref","is-referenced-by-count":5,"title":["The Region Centromeric to<i>HLA-C<\/i>Is a Key Region for Understanding the Phenotypic Variability of Psoriatic Arthritis"],"prefix":"10.1155","volume":"2014","author":[{"given":"Rub\u00e9n","family":"Queiro","sequence":"first","affiliation":[{"name":"Rheumatology Department, Hospital Universitario Central de Asturias (HUCA), C\/Celestino Villamil S\/N, 33006 Oviedo, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Tej\u00f3n","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Hospital Universitario Central de Asturias (HUCA), C\/Celestino Villamil S\/N, 33006 Oviedo, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Alonso","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Hospital Universitario Central de Asturias (HUCA), C\/Celestino Villamil S\/N, 33006 Oviedo, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo","family":"Coto","sequence":"additional","affiliation":[{"name":"Dermatology Department, HUCA, C\/Celestino Villamil S\/N, 33006 Oviedo, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"L\u00f3pez-Larrea","sequence":"additional","affiliation":[{"name":"Immunology Department, Histocompatibility Unit, HUCA, C\/Celestino Villamil S\/N, 33006 Oviedo, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jes\u00fas","family":"Mart\u00ednez-Borra","sequence":"additional","affiliation":[{"name":"Immunology Department, 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