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The dried sclerotia of <jats:italic>Poria cocos<\/jats:italic> Wolf (WPC) have been used for treating chronic edema and nephrosis. We evaluated the effects of WPC on puromycin aminonucleoside\u2010 (PAN\u2010) induced renal functional derangement and altered renal AQP2 and ENaC expression. In the nephrotic syndrome rat model, animals were injected with 75\u2009mg\/kg PAN and then treated with Losartan (30\u2009mg\u00b7kg<jats:sup>\u22121<\/jats:sup>\u00b7day<jats:sup>\u22121<\/jats:sup>) or WPC (200\u2009mg\u00b7kg<jats:sup>\u22121<\/jats:sup>\u00b7day<jats:sup>\u22121<\/jats:sup>) for 7 days. In the WPC group, proteinuria and ascites improved significantly. Plasma levels of triglyceride, total cholesterol, and low\u2010density lipoprotein\u2010 (LDL\u2010) cholesterol reduced significantly in the WPC group. In addition, the WPC group exhibited attenuation of the PAN\u2010induced increase in AQP2 and ENaC <jats:italic>\u03b1<\/jats:italic>\/<jats:italic>\u03b2<\/jats:italic> subunit protein and mRNA levels. WPC suppressed significantly PAN\u2010induced organic osmolyte regulators, reducing serum\u2010 and glucocorticoid\u2010inducible protein kinase (Sgk1) and sodium\u2010myo\u2010inositol cotransporter (SMIT) mRNA expression. Our results show that WPC improves nephrotic syndrome, including proteinuria and ascites, through inhibition of AQP2 and ENaC expression. Therefore, WPC influences body\u2010fluid regulation via inhibition of water and sodium channels, thereby, improving renal disorders such as edema or nephrosis.<\/jats:p>","DOI":"10.1155\/2014\/570420","type":"journal-article","created":{"date-parts":[[2014,8,9]],"date-time":"2014-08-09T21:07:49Z","timestamp":1407618469000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Effect of <i>Poria cocos<\/i> on Puromycin Aminonucleoside\u2010Induced Nephrotic Syndrome in Rats"],"prefix":"10.1155","volume":"2014","author":[{"given":"So Min","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun Jung","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung Joo","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9952-9697","authenticated-orcid":false,"given":"Dae Gill","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ho Sub","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,8,7]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.1186\/1423-0127-19-24"},{"key":"e_1_2_7_2_2","first-page":"10","article-title":"Altered expression of Reanl AQP1, AQP2 and NHE3 puromycin aminonucleoside induced nephrotic syndrome: intervention by alpha-MSH treatment","volume":"22","author":"Kwon T. 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