{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T20:20:10Z","timestamp":1790281210859,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,10,30]],"date-time":"2014-10-30T00:00:00Z","timestamp":1414627200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/100015528","name":"Universidad de la Laguna","doi-asserted-by":"publisher","award":["2013\/0001341"],"award-info":[{"award-number":["2013\/0001341"]}],"id":[{"id":"10.13039\/100015528","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Scholarly Research Notices"],"published-print":{"date-parts":[[2014,10,30]]},"abstract":"<jats:p>Neuromyelitis optica is an inflammatory disease characterized by neuritis and myelitis of the optic nerve. Its physiopathology is connected with the aquaporin-4 water channel, since antibodies against aquaporin-4 have been found in the cerebrospinal fluid and blood of neuromyelitis optica patients. The seropositivity for aquaporin-4 antibodies is used for the diagnosis of neuromyelitis optica or neuromyelitis optica spectrum disease. On the other hand, aquaporin-4 is expressed in astrocyte feet in the brain-blood barrier and subventricular zones of the brain ventricles. Aquaporin-4 expression is high in cerebrospinal fluid in hydrocephalus. Furthermore, neuroepithelial denudation precedes noncommunicating hydrocephalus and this neuroepithelial disruption could allow aquaporin-4 to reach anomalous brain areas where it is unrecognized and induce the generation of aquaporin-4 antibodies which could cause the neuromyelitis optica and certain types of hydrocephalus.<\/jats:p>","DOI":"10.1155\/2014\/580572","type":"journal-article","created":{"date-parts":[[2014,10,30]],"date-time":"2014-10-30T21:02:53Z","timestamp":1414702973000},"page":"1-5","source":"Crossref","is-referenced-by-count":3,"title":["The Neuroepithelium Disruption Could Generate Autoantibodies against AQP4 and Cause Neuromyelitis Optica and Hydrocephalus"],"prefix":"10.1155","volume":"2014","author":[{"given":"Leandro","family":"Casta\u00f1eyra-Ruiz","sequence":"first","affiliation":[{"name":"Departamento de Anatom\u00eda, Facultad de Medicina, Universidad de La Laguna, 38200 La Laguna, Tenerife, Islas Canarias, 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